TY - JOUR
T1 - Preservation of global and regional left ventricular function after early thrombolysis in acute myocardial infarction
AU - for the Working Group on Thrombolytic Therapy in Acute Myocardial Infarction of the Netherlands Interuniversity Cardiology Institute
AU - Serruys, Patrick W.
AU - Simoons, Maarten L.
AU - Suryapranata, Haryanto
AU - Vermeer, Frank
AU - Wijns, William
AU - Brand, Marcel van den
AU - Bär, Frits
AU - Zwaan, Chris
AU - Krauss, X. Hanno
AU - Remme, William J.
AU - Res, Jan
AU - Verheugt, Freek W.A.
AU - Domburg, Ronald van
AU - Lubsen, Jacobus
AU - Hugenholtz, Paul G.
PY - 1986
Y1 - 1986
N2 - The effect of early myocardial reperfusion (within 4 hours after onset of symptoms) on regional left ventricular function in patients with acute myocardial infarction has been quantitated by analysis of segmental wall motion. Of 533 patients randomized either to conventional coronary care unit therapy or to a reperfusion strategy, in 332 high quality angiograms were obtained 2 to 8 weeks after the onset of myocardial infarction. In those assigned to thrombolytic therapy, angiographic data were also available after acute reperfusion. Analysis on an “intention to treat” basis revealed significant preservation of left ventricular function after thrombolytic therapy (ejection fraction 53%) compared with conventional treatment (ejection fraction 47%). In addition, wall motion analysis showed significant improvement of regional function in the infarct zone in both inferior and anterior infarction. In addition, significant changes occurred in regional function of the remote “noninfarct zone” in the acute as well as the chronic stage. It is concluded that improved regional and global left ventricular function can be achieved with early reperfusion and that this is the likely explanation for the reduction of early and late mortality after thrombolysis observed in this study.
AB - The effect of early myocardial reperfusion (within 4 hours after onset of symptoms) on regional left ventricular function in patients with acute myocardial infarction has been quantitated by analysis of segmental wall motion. Of 533 patients randomized either to conventional coronary care unit therapy or to a reperfusion strategy, in 332 high quality angiograms were obtained 2 to 8 weeks after the onset of myocardial infarction. In those assigned to thrombolytic therapy, angiographic data were also available after acute reperfusion. Analysis on an “intention to treat” basis revealed significant preservation of left ventricular function after thrombolytic therapy (ejection fraction 53%) compared with conventional treatment (ejection fraction 47%). In addition, wall motion analysis showed significant improvement of regional function in the infarct zone in both inferior and anterior infarction. In addition, significant changes occurred in regional function of the remote “noninfarct zone” in the acute as well as the chronic stage. It is concluded that improved regional and global left ventricular function can be achieved with early reperfusion and that this is the likely explanation for the reduction of early and late mortality after thrombolysis observed in this study.
UR - https://www.scopus.com/pages/publications/0022644492
U2 - 10.1016/S0735-1097(86)80330-8
DO - 10.1016/S0735-1097(86)80330-8
M3 - Article
AN - SCOPUS:0022644492
SN - 0735-1097
VL - 7
SP - 729
EP - 742
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 4
ER -
