TY - JOUR
T1 - Preoperative measurement of cutaneous melanoma and nevi thickness with photoacoustic imaging
AU - Breathnach, Aedán
AU - Concannon, Elizabeth
AU - Dorairaj, Jemima J.
AU - Shaharan, Shazrinizam
AU - McGrath, James
AU - Jose, Jithin
AU - Kelly, Jack L.
AU - Leahy, Martin J.
N1 - Publisher Copyright:
© The Authors 2018. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Photoacoustic imaging (PAI) is an emerging biomedical imaging technology, which can potentially be used in the clinic to preoperatively measure melanoma thickness and guide biopsy depth and sample location. We recruited 27 patients with pigmented cutaneous lesions suspicious for melanoma to test the feasibility of a handheld linear-array photoacoustic probe in imaging lesion architecture and measuring tumor depth. The probe was assessed in terms of measurement accuracy, image quality, and ease of application. Photoacoustic scans included single wavelength, spectral unmixing, and three-dimensional (3-D) scans. The photoacoustically measured lesion thickness gave a high correlation with the histological thickness measured from resected surgical samples (r=0.99, P<0.001 for melanomas, r=0.98, P<0.001 for nevi). Thickness measurements were possible for 23 of 26 cases for nevi and all (6) cases for melanoma. Our results show that handheld, linear-array PAI is highly reliable in measuring cutaneous lesion thickness in vivo, and can potentially be used to inform biopsy procedure and improve patient management.
AB - Photoacoustic imaging (PAI) is an emerging biomedical imaging technology, which can potentially be used in the clinic to preoperatively measure melanoma thickness and guide biopsy depth and sample location. We recruited 27 patients with pigmented cutaneous lesions suspicious for melanoma to test the feasibility of a handheld linear-array photoacoustic probe in imaging lesion architecture and measuring tumor depth. The probe was assessed in terms of measurement accuracy, image quality, and ease of application. Photoacoustic scans included single wavelength, spectral unmixing, and three-dimensional (3-D) scans. The photoacoustically measured lesion thickness gave a high correlation with the histological thickness measured from resected surgical samples (r=0.99, P<0.001 for melanomas, r=0.98, P<0.001 for nevi). Thickness measurements were possible for 23 of 26 cases for nevi and all (6) cases for melanoma. Our results show that handheld, linear-array PAI is highly reliable in measuring cutaneous lesion thickness in vivo, and can potentially be used to inform biopsy procedure and improve patient management.
KW - Breslow depth
KW - biopsy
KW - histology
KW - spectral unmixing
KW - staging
UR - https://www.scopus.com/pages/publications/85042413297
U2 - 10.1117/1.JMI.5.1.015004
DO - 10.1117/1.JMI.5.1.015004
M3 - Article
SN - 2329-4302
VL - 5
JO - Journal of Medical Imaging
JF - Journal of Medical Imaging
IS - 1
M1 - 015004
ER -
