Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate

L. Giovagnini; E. Mancinetti; L. Ronconi; S. Sitran; L. Marchiò; I. Castagliuolo; P. Brun; A. Trevisan; D. Fregona

doi:10.1016/j.jinorgbio.2009.01.019

Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate

L. Giovagnini
, E. Mancinetti
, L. Ronconi
, S. Sitran
, L. Marchiò
, I. Castagliuolo
, P. Brun
, A. Trevisan
, D. Fregona

University of Padova
Consiglio Nazionale delle Ricerche
Physical Chemistry

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

17 Citations (Scopus)

Abstract

[RuCl₃ · nH₂O] and Na(trans-[RuCl₄(DMSO)₂]) were reacted with 1-pyrrolidinedithiocarbamate (PDT), its S-methyl ester (PDTM), and N,N-dimethylcarbamodithioic acid methyl ester (DMDTM) in water or methanol in order to obtain the corresponding Ru(III) derivatives. Once isolated and purified, the complexes were characterized by means of elemental analysis, conductivity measurements, FT-IR and ¹H NMR spectroscopy, ion electrospray mass spectrometry (ESI-MS), and thermal analyses. The crystal structure of mer-[Ru(DMDTM)(DMSO)Cl₃] has been also determined by X-ray crystallography. In vitro cytotoxic activity of all the synthesized complexes was eventually evaluated on some selected human tumor cell lines.

Original language	English
Pages (from-to)	774-782
Number of pages	9
Journal	Journal of Inorganic Biochemistry
Volume	103
Issue number	5
DOIs	https://doi.org/10.1016/j.jinorgbio.2009.01.019
Publication status	Published - May 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer drugs
Cytotoxic activity
Dithiocarbamates
Ruthenium(III) complexes

Access to Document

10.1016/j.jinorgbio.2009.01.019

Cite this

@article{a59bec77e00b410ba428045d77d8b5b9,

title = "Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate",

abstract = "[RuCl3 · nH2O] and Na(trans-[RuCl4(DMSO)2]) were reacted with 1-pyrrolidinedithiocarbamate (PDT), its S-methyl ester (PDTM), and N,N-dimethylcarbamodithioic acid methyl ester (DMDTM) in water or methanol in order to obtain the corresponding Ru(III) derivatives. Once isolated and purified, the complexes were characterized by means of elemental analysis, conductivity measurements, FT-IR and 1H NMR spectroscopy, ion electrospray mass spectrometry (ESI-MS), and thermal analyses. The crystal structure of mer-[Ru(DMDTM)(DMSO)Cl3] has been also determined by X-ray crystallography. In vitro cytotoxic activity of all the synthesized complexes was eventually evaluated on some selected human tumor cell lines.",

keywords = "Anticancer drugs, Cytotoxic activity, Dithiocarbamates, Ruthenium(III) complexes",

author = "L. Giovagnini and E. Mancinetti and L. Ronconi and S. Sitran and L. Marchi{\`o} and I. Castagliuolo and P. Brun and A. Trevisan and D. Fregona",

year = "2009",

month = may,

doi = "10.1016/j.jinorgbio.2009.01.019",

language = "English",

volume = "103",

pages = "774--782",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate

AU - Giovagnini, L.

AU - Mancinetti, E.

AU - Ronconi, L.

AU - Sitran, S.

AU - Marchiò, L.

AU - Castagliuolo, I.

AU - Brun, P.

AU - Trevisan, A.

AU - Fregona, D.

PY - 2009/5

Y1 - 2009/5

N2 - [RuCl3 · nH2O] and Na(trans-[RuCl4(DMSO)2]) were reacted with 1-pyrrolidinedithiocarbamate (PDT), its S-methyl ester (PDTM), and N,N-dimethylcarbamodithioic acid methyl ester (DMDTM) in water or methanol in order to obtain the corresponding Ru(III) derivatives. Once isolated and purified, the complexes were characterized by means of elemental analysis, conductivity measurements, FT-IR and 1H NMR spectroscopy, ion electrospray mass spectrometry (ESI-MS), and thermal analyses. The crystal structure of mer-[Ru(DMDTM)(DMSO)Cl3] has been also determined by X-ray crystallography. In vitro cytotoxic activity of all the synthesized complexes was eventually evaluated on some selected human tumor cell lines.

AB - [RuCl3 · nH2O] and Na(trans-[RuCl4(DMSO)2]) were reacted with 1-pyrrolidinedithiocarbamate (PDT), its S-methyl ester (PDTM), and N,N-dimethylcarbamodithioic acid methyl ester (DMDTM) in water or methanol in order to obtain the corresponding Ru(III) derivatives. Once isolated and purified, the complexes were characterized by means of elemental analysis, conductivity measurements, FT-IR and 1H NMR spectroscopy, ion electrospray mass spectrometry (ESI-MS), and thermal analyses. The crystal structure of mer-[Ru(DMDTM)(DMSO)Cl3] has been also determined by X-ray crystallography. In vitro cytotoxic activity of all the synthesized complexes was eventually evaluated on some selected human tumor cell lines.

KW - Anticancer drugs

KW - Cytotoxic activity

KW - Dithiocarbamates

KW - Ruthenium(III) complexes

UR - https://www.scopus.com/pages/publications/64449087132

U2 - 10.1016/j.jinorgbio.2009.01.019

DO - 10.1016/j.jinorgbio.2009.01.019

M3 - Article

SN - 0162-0134

VL - 103

SP - 774

EP - 782

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 5

ER -

Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this