Predictive utility of preoperative nt-probnp levels on cardiovascular outcomes of abdominal aortic aneurysm repair

Background: Non-cardiac vascular surgery (NCVS) can have an elevated risk of peri-procedural complications. Prediction of the outcomes following surgical interventions provides an important advantage of risk stratification. This study aims to assess the predictive utility of pre-operative NT-proBNP levels on the cardiovascular (CV) outcomes of abdominal aortic aneurysm (AAA) repair. Methods: A retrospective data analysis of all the patients who underwent AAA repair, both open surgical repair (OSR) and endovascular aneurysm repair (EVAR), was performed in our tertiary care hospital from 2002 to 2018. Results: A total of 99 AAAs repair (63 EVAR and 36 OSR) were included in the study. Five (5.05%) patients experienced Myocardial Infarction (MI) in the post-operative period. Median preoperative NT-proBNP levels in patients with post-intervention MI were significantly higher than the ones without MI (1431 pg/mL vs 192 pg/mL, P=0.03). Similarly, higher median preoperative NT-proBNP levels was found in patients with 30-day postoperative mortality (944 pg/mL vs 197 pg/mL, P=0.136) and 30-day morbidity (352 pg/mL vs 192 pg/mL, P=0.021). Conclusion: Preoperative NT-proBNP levels were higher in patients with adverse surgical outcomes after the aortic intervention. Predictive utility of NT-proBNP and routine measurement of this biomarker could potentially improve CV risk stratification in NCVS.