Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia

Stanley Zammit; Gaynor Jones; Susan J. Jones; Nadine Norton; Robert D. Sanders; Charis Milham; Geraldine M. McCarthy; Lisa A. Jones; Alastair G. Cardno; Marion Gray; Kieran C. Murphy; Michael C. O'Donovan; Michael J. Owen

doi:10.1002/ajmg.b.30021

Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia

Stanley Zammit
, Gaynor Jones
, Susan J. Jones
, Nadine Norton
, Robert D. Sanders
, Charis Milham
, Geraldine M. McCarthy
, Lisa A. Jones
, Alastair G. Cardno
, Marion Gray
, Kieran C. Murphy
, Michael C. O'Donovan
, Michael J. Owen

Cardiff University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

77 Citations (Scopus)

Abstract

Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined he relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.

Original language	English
Pages (from-to)	19-20
Number of pages	2
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	128 B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.30021
Publication status	Published - 1 Jul 2004
Externally published	Yes

Keywords

Aggression
Association
Catecholamines
Epistasis
Functional

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10.1002/ajmg.b.30021

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Zammit, S., Jones, G., Jones, S. J., Norton, N., Sanders, R. D., Milham, C., McCarthy, G. M., Jones, L. A., Cardno, A. G., Gray, M., Murphy, K. C., O'Donovan, M. C., & Owen, M. J. (2004). Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 128 B(1), 19-20. https://doi.org/10.1002/ajmg.b.30021

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title = "Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia",

abstract = "Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined he relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.",

keywords = "Aggression, Association, Catecholamines, Epistasis, Functional",

author = "Stanley Zammit and Gaynor Jones and Jones, \{Susan J.\} and Nadine Norton and Sanders, \{Robert D.\} and Charis Milham and McCarthy, \{Geraldine M.\} and Jones, \{Lisa A.\} and Cardno, \{Alastair G.\} and Marion Gray and Murphy, \{Kieran C.\} and O'Donovan, \{Michael C.\} and Owen, \{Michael J.\}",

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Zammit, S, Jones, G, Jones, SJ, Norton, N, Sanders, RD, Milham, C, McCarthy, GM, Jones, LA, Cardno, AG, Gray, M, Murphy, KC, O'Donovan, MC & Owen, MJ 2004, 'Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 128 B, no. 1, pp. 19-20. https://doi.org/10.1002/ajmg.b.30021

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AU - Zammit, Stanley

AU - Jones, Gaynor

AU - Jones, Susan J.

AU - Norton, Nadine

AU - Sanders, Robert D.

AU - Milham, Charis

AU - McCarthy, Geraldine M.

AU - Jones, Lisa A.

AU - Cardno, Alastair G.

AU - Gray, Marion

AU - Murphy, Kieran C.

AU - O'Donovan, Michael C.

AU - Owen, Michael J.

PY - 2004/7/1

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N2 - Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined he relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.

AB - Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined he relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.

KW - Aggression

KW - Association

KW - Catecholamines

KW - Epistasis

KW - Functional

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DO - 10.1002/ajmg.b.30021

M3 - Article

SN - 1552-4841

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JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

IS - 1

ER -

Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia

Abstract

Keywords

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