Plasmodium falciparum: New molecular targets with potential for antimalarial drug development

Donald L. Gardiner; Tina S. Skinner-Adams; Christopher L. Brown; Katherine T. Andrews; Colin M. Stack; James S. McCarthy; John P. Dalton; Katharine R. Trenholme

doi:10.1586/ERI.09.93

Plasmodium falciparum: New molecular targets with potential for antimalarial drug development

Donald L. Gardiner
, Tina S. Skinner-Adams
, Christopher L. Brown
, Katherine T. Andrews
, Colin M. Stack
, James S. McCarthy
, John P. Dalton
, Katharine R. Trenholme

QIMR Berghofer Medical Research Institute
Griffith University
University of Western Sydney
University of Queensland
McGill University, Macdonald Campus

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

35 Citations (Scopus)

Abstract

Malaria remains one of the world's most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase.

Original language	English
Pages (from-to)	1087-1098
Number of pages	12
Journal	Expert Review of Anti-Infective Therapy
Volume	7
Issue number	9
DOIs	https://doi.org/10.1586/ERI.09.93
Publication status	Published - Nov 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aminopeptidase
Aspartic protease
Histone deacetylase
Hypoxanthine-xanthine- guanine phosphoribosyltransferase
Malaria
Molecular target
Plasmepsin
Plasmodium falciparum

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10.1586/ERI.09.93

Cite this

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title = "Plasmodium falciparum: New molecular targets with potential for antimalarial drug development",

abstract = "Malaria remains one of the world's most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase.",

keywords = "Aminopeptidase, Aspartic protease, Histone deacetylase, Hypoxanthine-xanthine- guanine phosphoribosyltransferase, Malaria, Molecular target, Plasmepsin, Plasmodium falciparum",

author = "Gardiner, \{Donald L.\} and Skinner-Adams, \{Tina S.\} and Brown, \{Christopher L.\} and Andrews, \{Katherine T.\} and Stack, \{Colin M.\} and McCarthy, \{James S.\} and Dalton, \{John P.\} and Trenholme, \{Katharine R.\}",

year = "2009",

month = nov,

doi = "10.1586/ERI.09.93",

language = "English",

volume = "7",

pages = "1087--1098",

journal = "Expert Review of Anti-Infective Therapy",

issn = "1478-7210",

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T1 - Plasmodium falciparum

T2 - New molecular targets with potential for antimalarial drug development

AU - Gardiner, Donald L.

AU - Skinner-Adams, Tina S.

AU - Brown, Christopher L.

AU - Andrews, Katherine T.

AU - Stack, Colin M.

AU - McCarthy, James S.

AU - Dalton, John P.

AU - Trenholme, Katharine R.

PY - 2009/11

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N2 - Malaria remains one of the world's most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase.

AB - Malaria remains one of the world's most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase.

KW - Aminopeptidase

KW - Aspartic protease

KW - Histone deacetylase

KW - Hypoxanthine-xanthine- guanine phosphoribosyltransferase

KW - Malaria

KW - Molecular target

KW - Plasmepsin

KW - Plasmodium falciparum

UR - https://www.scopus.com/pages/publications/73949130820

U2 - 10.1586/ERI.09.93

DO - 10.1586/ERI.09.93

M3 - Review article

C2 - 19883329

AN - SCOPUS:73949130820

SN - 1478-7210

VL - 7

SP - 1087

EP - 1098

JO - Expert Review of Anti-Infective Therapy

JF - Expert Review of Anti-Infective Therapy

IS - 9

ER -

Plasmodium falciparum: New molecular targets with potential for antimalarial drug development

Abstract

UN SDGs

Keywords

Access to Document

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