Photoreaction pathways for the anticancer complex trans,trans,trans- [Pt(N3)2(OH)2(NH3)2]

Luca Ronconi; Peter J. Sadler

doi:10.1039/c0dt00546k

Photoreaction pathways for the anticancer complex trans,trans,trans- [Pt(N₃)₂(OH)₂(NH₃)₂]

Luca Ronconi
, Peter J. Sadler

University of Edinburgh
University of Padova
University of Warwick

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

58 Citations (Scopus)

Abstract

The photodecomposition of the anticancer complex trans,trans,trans- [Pt(N₃)₂(OH)₂(NH₃)₂] in acidic aqueous solution, as well as in phosphate-buffered saline (PBS), induced by UVA light (centred at λ = 365 nm) has been studied by multinuclear NMR spectroscopy. We show that the photoreaction pathway in PBS, which involves azide release, differs from that in acidic aqueous conditions, under which N₂ is a major product. In both cases, a number of trans-{N-Pt(ii/iv)-NH₃} species were also observed as photoproducts, as well as the evolution of O₂ and release of free ammonia with a subsequent increase in pH. The results from this study illustrate that photoinduced reactions of Pt(iv)-diazido derivatives can lead to novel reaction pathways, and therefore potentially to new cytotoxic mechanisms in cancer cells.

Original language	English
Pages (from-to)	262-268
Number of pages	7
Journal	Dalton Transactions
Volume	40
Issue number	1
DOIs	https://doi.org/10.1039/c0dt00546k
Publication status	Published - 7 Jan 2011
Externally published	Yes

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title = "Photoreaction pathways for the anticancer complex trans,trans,trans- [Pt(N3)2(OH)2(NH3)2]",

abstract = "The photodecomposition of the anticancer complex trans,trans,trans- [Pt(N3)2(OH)2(NH3)2] in acidic aqueous solution, as well as in phosphate-buffered saline (PBS), induced by UVA light (centred at λ = 365 nm) has been studied by multinuclear NMR spectroscopy. We show that the photoreaction pathway in PBS, which involves azide release, differs from that in acidic aqueous conditions, under which N2 is a major product. In both cases, a number of trans-\{N-Pt(ii/iv)-NH3\} species were also observed as photoproducts, as well as the evolution of O2 and release of free ammonia with a subsequent increase in pH. The results from this study illustrate that photoinduced reactions of Pt(iv)-diazido derivatives can lead to novel reaction pathways, and therefore potentially to new cytotoxic mechanisms in cancer cells.",

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AB - The photodecomposition of the anticancer complex trans,trans,trans- [Pt(N3)2(OH)2(NH3)2] in acidic aqueous solution, as well as in phosphate-buffered saline (PBS), induced by UVA light (centred at λ = 365 nm) has been studied by multinuclear NMR spectroscopy. We show that the photoreaction pathway in PBS, which involves azide release, differs from that in acidic aqueous conditions, under which N2 is a major product. In both cases, a number of trans-{N-Pt(ii/iv)-NH3} species were also observed as photoproducts, as well as the evolution of O2 and release of free ammonia with a subsequent increase in pH. The results from this study illustrate that photoinduced reactions of Pt(iv)-diazido derivatives can lead to novel reaction pathways, and therefore potentially to new cytotoxic mechanisms in cancer cells.

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Photoreaction pathways for the anticancer complex trans,trans,trans- [Pt(N₃)₂(OH)₂(NH₃)₂]

Abstract

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