Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase

Francis J. Giles; Eric J. Feldman; Gail J. Roboz; Richard A. Larson; Steven W. Mamus; Jorge E. Cortes; Srdan Verstovsek; Stefan Faderl; Moshe Talpaz; Miloslav Beran; Maher Albitar; Susan M. O'Brien; Hagop M. Kantarjian

doi:10.1016/S0145-2126(03)00094-8

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase

Francis J. Giles, Eric J. Feldman, Gail J. Roboz, Richard A. Larson, Steven W. Mamus, Jorge E. Cortes, Srdan Verstovsek, Stefan Faderl, Moshe Talpaz, Miloslav Beran, Maher Albitar, Susan M. O'Brien, Hagop M. Kantarjian

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

21 Citations (Scopus)

Abstract

A phase II study of troxacitabine, a non-natural dioxolane nucleoside L-enantiomer, was conducted in patients with chronic myelogenous leukemia in blastic phase (CML-BP). Patients were untreated for BP, or treated with imatinib mesylate (IM) as sole prior therapy for BP. Troxacitabine was given as an intravenous infusion over 30min daily for 5 days at a dose of 8.0mg/m² per day. Thirty-one patients, 29 (93%) of whom had failed prior IM therapy, received 51 courses of therapy. Grade 3 or 4 toxicities included stomatitis (4%), hand-foot syndrome (18%), and skin rash (12%). Four patients (13%) responded. Troxacitabine-based combinations merit study in IM-resistant CML.

Original language	English
Pages (from-to)	1091-1096
Number of pages	6
Journal	Leukemia Research
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/S0145-2126(03)00094-8
Publication status	Published - 1 Dec 2003
Externally published	Yes

Keywords

Blast phase
Chronic myelogenous leukemia
Imatinib mesylate
Troxacitabine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0145-2126(03)00094-8

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Giles, F. J., Feldman, E. J., Roboz, G. J., Larson, R. A., Mamus, S. W., Cortes, J. E., Verstovsek, S., Faderl, S., Talpaz, M., Beran, M., Albitar, M., O'Brien, S. M., & Kantarjian, H. M. (2003). Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase. Leukemia Research, 27(12), 1091-1096. https://doi.org/10.1016/S0145-2126(03)00094-8

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title = "Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase",

abstract = "A phase II study of troxacitabine, a non-natural dioxolane nucleoside L-enantiomer, was conducted in patients with chronic myelogenous leukemia in blastic phase (CML-BP). Patients were untreated for BP, or treated with imatinib mesylate (IM) as sole prior therapy for BP. Troxacitabine was given as an intravenous infusion over 30min daily for 5 days at a dose of 8.0mg/m2 per day. Thirty-one patients, 29 (93%) of whom had failed prior IM therapy, received 51 courses of therapy. Grade 3 or 4 toxicities included stomatitis (4%), hand-foot syndrome (18%), and skin rash (12%). Four patients (13%) responded. Troxacitabine-based combinations merit study in IM-resistant CML.",

keywords = "Blast phase, Chronic myelogenous leukemia, Imatinib mesylate, Troxacitabine",

author = "Giles, {Francis J.} and Feldman, {Eric J.} and Roboz, {Gail J.} and Larson, {Richard A.} and Mamus, {Steven W.} and Cortes, {Jorge E.} and Srdan Verstovsek and Stefan Faderl and Moshe Talpaz and Miloslav Beran and Maher Albitar and O'Brien, {Susan M.} and Kantarjian, {Hagop M.}",

year = "2003",

month = dec,

day = "1",

doi = "10.1016/S0145-2126(03)00094-8",

language = "English",

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Giles, FJ, Feldman, EJ, Roboz, GJ, Larson, RA, Mamus, SW, Cortes, JE, Verstovsek, S, Faderl, S, Talpaz, M, Beran, M, Albitar, M, O'Brien, SM & Kantarjian, HM 2003, 'Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase', Leukemia Research, vol. 27, no. 12, pp. 1091-1096. https://doi.org/10.1016/S0145-2126(03)00094-8

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase. / Giles, Francis J.; Feldman, Eric J.; Roboz, Gail J. et al.
In: Leukemia Research, Vol. 27, No. 12, 01.12.2003, p. 1091-1096.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

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AU - Giles, Francis J.

AU - Feldman, Eric J.

AU - Roboz, Gail J.

AU - Larson, Richard A.

AU - Mamus, Steven W.

AU - Cortes, Jorge E.

AU - Verstovsek, Srdan

AU - Faderl, Stefan

AU - Talpaz, Moshe

AU - Beran, Miloslav

AU - Albitar, Maher

AU - O'Brien, Susan M.

AU - Kantarjian, Hagop M.

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N2 - A phase II study of troxacitabine, a non-natural dioxolane nucleoside L-enantiomer, was conducted in patients with chronic myelogenous leukemia in blastic phase (CML-BP). Patients were untreated for BP, or treated with imatinib mesylate (IM) as sole prior therapy for BP. Troxacitabine was given as an intravenous infusion over 30min daily for 5 days at a dose of 8.0mg/m2 per day. Thirty-one patients, 29 (93%) of whom had failed prior IM therapy, received 51 courses of therapy. Grade 3 or 4 toxicities included stomatitis (4%), hand-foot syndrome (18%), and skin rash (12%). Four patients (13%) responded. Troxacitabine-based combinations merit study in IM-resistant CML.

AB - A phase II study of troxacitabine, a non-natural dioxolane nucleoside L-enantiomer, was conducted in patients with chronic myelogenous leukemia in blastic phase (CML-BP). Patients were untreated for BP, or treated with imatinib mesylate (IM) as sole prior therapy for BP. Troxacitabine was given as an intravenous infusion over 30min daily for 5 days at a dose of 8.0mg/m2 per day. Thirty-one patients, 29 (93%) of whom had failed prior IM therapy, received 51 courses of therapy. Grade 3 or 4 toxicities included stomatitis (4%), hand-foot syndrome (18%), and skin rash (12%). Four patients (13%) responded. Troxacitabine-based combinations merit study in IM-resistant CML.

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KW - Chronic myelogenous leukemia

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KW - Troxacitabine

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SN - 0145-2126

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JO - Leukemia Research

JF - Leukemia Research

IS - 12

ER -

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase

Abstract

Keywords

UN SDGs

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