Performance Review of Multiple Reference Versus Time Domain Optical Coherence Tomography

Kai Neuhaus; Paul M. McNamara; Sergey Alexandrov; Sean O'Gorman; Josh Hogan; Carol Wilson; Martin J. Leahy

doi:10.1109/JPHOT.2018.2828419

Performance Review of Multiple Reference Versus Time Domain Optical Coherence Tomography

Kai Neuhaus, Paul M. McNamara, Sergey Alexandrov, Sean O'Gorman, Josh Hogan, Carol Wilson, Martin J. Leahy

Physics

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

5 Citations (Scopus)

Abstract

We present a detailed characterization of noise sources in multiple reference optical coherence tomography (MR-OCT) compared to time-domain OCT (TD-OCT). The noise characteristics were modeled based on the TD-OCT noise model and modified for MR-OCT and confirmed with measurements. The MR-OCT sensitivity characteristics are significantly affected by the reflection from the partial mirror, which also introduces a natural attenuation in the reference arm, partially matching the reflectivity intensity profile of human tissue. At optimal balance between sample and reference arm and using balanced detection, the peak sensitivity was measured to be 95 dB, which is close to simple Fourier-domain systems. The results provide a better understanding of the application range for MR-OCT and higher order effects observed, suggesting a nontrivial noise model for MR-OCT.

Original language	English
Article number	3400214
Journal	IEEE Photonics Journal
Volume	10
Issue number	3
DOIs	https://doi.org/10.1109/JPHOT.2018.2828419
Publication status	Published - Jun 2018

Keywords

Biophotonics Instrumentation
Coherent imaging
Heterodyne
Heterodyning
Optical coherence tomography

Access to Document

10.1109/JPHOT.2018.2828419

Cite this

@article{40ca5c9697f541d49f717ddbb0e58711,

title = "Performance Review of Multiple Reference Versus Time Domain Optical Coherence Tomography",

abstract = "We present a detailed characterization of noise sources in multiple reference optical coherence tomography (MR-OCT) compared to time-domain OCT (TD-OCT). The noise characteristics were modeled based on the TD-OCT noise model and modified for MR-OCT and confirmed with measurements. The MR-OCT sensitivity characteristics are significantly affected by the reflection from the partial mirror, which also introduces a natural attenuation in the reference arm, partially matching the reflectivity intensity profile of human tissue. At optimal balance between sample and reference arm and using balanced detection, the peak sensitivity was measured to be 95 dB, which is close to simple Fourier-domain systems. The results provide a better understanding of the application range for MR-OCT and higher order effects observed, suggesting a nontrivial noise model for MR-OCT.",

keywords = "Biophotonics Instrumentation, Coherent imaging, Heterodyne, Heterodyning, Optical coherence tomography",

author = "Kai Neuhaus and McNamara, \{Paul M.\} and Sergey Alexandrov and Sean O'Gorman and Josh Hogan and Carol Wilson and Leahy, \{Martin J.\}",

note = "Publisher Copyright: {\textcopyright} 2009-2012 IEEE.",

year = "2018",

month = jun,

doi = "10.1109/JPHOT.2018.2828419",

language = "English",

volume = "10",

journal = "IEEE Photonics Journal",

issn = "1943-0655",

number = "3",

}

TY - JOUR

T1 - Performance Review of Multiple Reference Versus Time Domain Optical Coherence Tomography

AU - Neuhaus, Kai

AU - McNamara, Paul M.

AU - Alexandrov, Sergey

AU - O'Gorman, Sean

AU - Hogan, Josh

AU - Wilson, Carol

AU - Leahy, Martin J.

PY - 2018/6

Y1 - 2018/6

N2 - We present a detailed characterization of noise sources in multiple reference optical coherence tomography (MR-OCT) compared to time-domain OCT (TD-OCT). The noise characteristics were modeled based on the TD-OCT noise model and modified for MR-OCT and confirmed with measurements. The MR-OCT sensitivity characteristics are significantly affected by the reflection from the partial mirror, which also introduces a natural attenuation in the reference arm, partially matching the reflectivity intensity profile of human tissue. At optimal balance between sample and reference arm and using balanced detection, the peak sensitivity was measured to be 95 dB, which is close to simple Fourier-domain systems. The results provide a better understanding of the application range for MR-OCT and higher order effects observed, suggesting a nontrivial noise model for MR-OCT.

AB - We present a detailed characterization of noise sources in multiple reference optical coherence tomography (MR-OCT) compared to time-domain OCT (TD-OCT). The noise characteristics were modeled based on the TD-OCT noise model and modified for MR-OCT and confirmed with measurements. The MR-OCT sensitivity characteristics are significantly affected by the reflection from the partial mirror, which also introduces a natural attenuation in the reference arm, partially matching the reflectivity intensity profile of human tissue. At optimal balance between sample and reference arm and using balanced detection, the peak sensitivity was measured to be 95 dB, which is close to simple Fourier-domain systems. The results provide a better understanding of the application range for MR-OCT and higher order effects observed, suggesting a nontrivial noise model for MR-OCT.

KW - Biophotonics Instrumentation

KW - Coherent imaging

KW - Heterodyne

KW - Heterodyning

KW - Optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=85045732939&partnerID=8YFLogxK

U2 - 10.1109/JPHOT.2018.2828419

DO - 10.1109/JPHOT.2018.2828419

M3 - Article

SN - 1943-0655

VL - 10

JO - IEEE Photonics Journal

JF - IEEE Photonics Journal

IS - 3

M1 - 3400214

ER -

Performance Review of Multiple Reference Versus Time Domain Optical Coherence Tomography

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this