PEG based hyperbranched polymeric hollow nanospheres

Hongliang Cao; Yixiao Dong; Suzanne O'Rorke; Wenxin Wang; Abhay Pandit

doi:10.1088/0957-4484/22/6/065604

PEG based hyperbranched polymeric hollow nanospheres

Hongliang Cao
, Yixiao Dong
, Suzanne O'Rorke
, Wenxin Wang
, Abhay Pandit

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

4 Citations (Scopus)

Abstract

The synthesis of a new PEG based hyperbranched copolymer of poly(ethylene glycol) methyl ether methacrylate-co-ethylene glycol dimethacrylate (PEGMEMA-co-EGDMA) was achieved via a one-step in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). Then, hollow PEG based nanospheres were fabricated from this polymer using a solvent evaporation method and post-stabilisation strategy. Furthermore, the analysis using a cellular metabolic activity assay proved that the copolymer did not affect cellular metabolism, indicating that this PEG based polymeric nanosphere has potential for use in drug delivery applications.

Original language	English
Article number	065604
Journal	Nanotechnology
Volume	22
Issue number	6
DOIs	https://doi.org/10.1088/0957-4484/22/6/065604
Publication status	Published - 11 Feb 2011
Externally published	Yes

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AU - Cao, Hongliang

AU - Dong, Yixiao

AU - O'Rorke, Suzanne

AU - Wang, Wenxin

AU - Pandit, Abhay

PY - 2011/2/11

Y1 - 2011/2/11

N2 - The synthesis of a new PEG based hyperbranched copolymer of poly(ethylene glycol) methyl ether methacrylate-co-ethylene glycol dimethacrylate (PEGMEMA-co-EGDMA) was achieved via a one-step in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). Then, hollow PEG based nanospheres were fabricated from this polymer using a solvent evaporation method and post-stabilisation strategy. Furthermore, the analysis using a cellular metabolic activity assay proved that the copolymer did not affect cellular metabolism, indicating that this PEG based polymeric nanosphere has potential for use in drug delivery applications.

AB - The synthesis of a new PEG based hyperbranched copolymer of poly(ethylene glycol) methyl ether methacrylate-co-ethylene glycol dimethacrylate (PEGMEMA-co-EGDMA) was achieved via a one-step in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). Then, hollow PEG based nanospheres were fabricated from this polymer using a solvent evaporation method and post-stabilisation strategy. Furthermore, the analysis using a cellular metabolic activity assay proved that the copolymer did not affect cellular metabolism, indicating that this PEG based polymeric nanosphere has potential for use in drug delivery applications.

UR - https://www.scopus.com/pages/publications/79251547389

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PEG based hyperbranched polymeric hollow nanospheres

Abstract

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