Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines

G. Cserni; I. Amendoeira; N. Apostolikas; J. P. Bellocq; S. Bianchi; G. Bussolati; W. Boecker; B. Borisch; C. E. Connolly; T. Decker; P. Dervan; M. Drijkoningen; I. O. Ellis; C. W. Elston; V. Eusebi; D. Faverly; P. Heikkila; R. Holland; H. Kerner; J. Kulka; J. Jacquemier; M. Lacerda; J. Martinez-Penuela; C. De Miguel; J. L. Peterse; F. Rank; P. Regitnig; A. Reiner; A. Sapino; B. Sigal-Zafrani; A. M. Tanous; S. Thorstenson; E. Zozaya; C. A. Wells

doi:10.1016/S0959-8049(03)00203-X

Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines

G. Cserni
, I. Amendoeira
, N. Apostolikas
, J. P. Bellocq
, S. Bianchi
, G. Bussolati
, W. Boecker
, B. Borisch
, C. E. Connolly
, T. Decker
, P. Dervan
, M. Drijkoningen
, I. O. Ellis
, C. W. Elston
, V. Eusebi
, D. Faverly
, P. Heikkila
, R. Holland
, H. Kerner
, J. Kulka

J. Jacquemier, M. Lacerda, J. Martinez-Penuela, C. De Miguel, J. L. Peterse, F. Rank, P. Regitnig, A. Reiner, A. Sapino, B. Sigal-Zafrani, A. M. Tanous, S. Thorstenson, E. Zozaya, C. A. Wells

Bács-Kiskun Co. Teach. Hosp.
University of Porto
Saint Savvas Hospital
Hôpitaux Universitaires de Strasbourg
University of Florence
Ist. di Anat. e Istologia Patologica
Gerhard-Domagk Inst. fur Pathologie
University of Geneva
Galway University Hospital
HELIOS Medical Centre
Mater Hospital
KU Leuven– University Hospital Leuven
Nottingham City Hospital
University of Bologna
CMP Laboratory
Haartman Institute
Radboud University Nijmegen Medical Center
Rambam Medical Center
Semmelweis University
Institut Paoli Calmettes
Laboratorio de Histopatologica
Hospital de Navarra
The Netherlands Cancer Institute
University Hospital of Copenhagen - Rigshospitalet
University of Graz
Res. Inst. of Molecular Pathology
France BioImaging INBS
Kalmar County Hospital
Barts and The London School of Medicine and Dentistry

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

202 Citations (Scopus)

Abstract

Controversies and inconsistencies regarding the pathological work-up of sentinel lymph nodes (SNs) led the European Working Group for Breast Screening Pathology (EWGBSP) to review published data and current evidence that can promote the formulation of European guidelines for the pathological work-up of SNs. After an evaluation of the accuracy of SN biopsy as a staging procedure, the yields of different sectioning methods and the immunohistochemical detection of metastatic cells are reviewed. Currently published data do not allow the significance of micrometastases or isolated tumour cells to be established, but it is suggested that approximately 18% of the cases may be associated with further nodal (non-SN) metastases, i.e. approximately 2% of all patients initially staged by SN biopsy. The methods for the intraoperative and molecular assessment of SNs are also surveyed.

Original language	English
Pages (from-to)	1654-1667
Number of pages	14
Journal	European Journal of Cancer
Volume	39
Issue number	12
DOIs	https://doi.org/10.1016/S0959-8049(03)00203-X
Publication status	Published - Aug 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Frozen section
Intraoperative cytology
Isolated tumour cell
Micrometastasis
Molecular analysis
Non-sentinel node metastasis
Occult metastasis
Sentinel lymph nodes
Survival

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10.1016/S0959-8049(03)00203-X

Cite this

Cserni, G., Amendoeira, I., Apostolikas, N., Bellocq, J. P., Bianchi, S., Bussolati, G., Boecker, W., Borisch, B., Connolly, C. E., Decker, T., Dervan, P., Drijkoningen, M., Ellis, I. O., Elston, C. W., Eusebi, V., Faverly, D., Heikkila, P., Holland, R., Kerner, H., ... Wells, C. A. (2003). Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines. European Journal of Cancer, 39(12), 1654-1667. https://doi.org/10.1016/S0959-8049(03)00203-X

@article{b38ff4d3d6ee48c09aa74c073bdeebee,

title = "Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines",

abstract = "Controversies and inconsistencies regarding the pathological work-up of sentinel lymph nodes (SNs) led the European Working Group for Breast Screening Pathology (EWGBSP) to review published data and current evidence that can promote the formulation of European guidelines for the pathological work-up of SNs. After an evaluation of the accuracy of SN biopsy as a staging procedure, the yields of different sectioning methods and the immunohistochemical detection of metastatic cells are reviewed. Currently published data do not allow the significance of micrometastases or isolated tumour cells to be established, but it is suggested that approximately 18\% of the cases may be associated with further nodal (non-SN) metastases, i.e. approximately 2\% of all patients initially staged by SN biopsy. The methods for the intraoperative and molecular assessment of SNs are also surveyed.",

keywords = "Breast cancer, Frozen section, Intraoperative cytology, Isolated tumour cell, Micrometastasis, Molecular analysis, Non-sentinel node metastasis, Occult metastasis, Sentinel lymph nodes, Survival",

author = "G. Cserni and I. Amendoeira and N. Apostolikas and Bellocq, \{J. P.\} and S. Bianchi and G. Bussolati and W. Boecker and B. Borisch and Connolly, \{C. E.\} and T. Decker and P. Dervan and M. Drijkoningen and Ellis, \{I. O.\} and Elston, \{C. W.\} and V. Eusebi and D. Faverly and P. Heikkila and R. Holland and H. Kerner and J. Kulka and J. Jacquemier and M. Lacerda and J. Martinez-Penuela and \{De Miguel\}, C. and Peterse, \{J. L.\} and F. Rank and P. Regitnig and A. Reiner and A. Sapino and B. Sigal-Zafrani and Tanous, \{A. M.\} and S. Thorstenson and E. Zozaya and Wells, \{C. A.\}",

year = "2003",

month = aug,

doi = "10.1016/S0959-8049(03)00203-X",

language = "English",

volume = "39",

pages = "1654--1667",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd",

number = "12",

}

Cserni, G, Amendoeira, I, Apostolikas, N, Bellocq, JP, Bianchi, S, Bussolati, G, Boecker, W, Borisch, B, Connolly, CE, Decker, T, Dervan, P, Drijkoningen, M, Ellis, IO, Elston, CW, Eusebi, V, Faverly, D, Heikkila, P, Holland, R, Kerner, H, Kulka, J, Jacquemier, J, Lacerda, M, Martinez-Penuela, J, De Miguel, C, Peterse, JL, Rank, F, Regitnig, P, Reiner, A, Sapino, A, Sigal-Zafrani, B, Tanous, AM, Thorstenson, S, Zozaya, E & Wells, CA 2003, 'Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines', European Journal of Cancer, vol. 39, no. 12, pp. 1654-1667. https://doi.org/10.1016/S0959-8049(03)00203-X

TY - JOUR

T1 - Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines

AU - Cserni, G.

AU - Amendoeira, I.

AU - Apostolikas, N.

AU - Bellocq, J. P.

AU - Bianchi, S.

AU - Bussolati, G.

AU - Boecker, W.

AU - Borisch, B.

AU - Connolly, C. E.

AU - Decker, T.

AU - Dervan, P.

AU - Drijkoningen, M.

AU - Ellis, I. O.

AU - Elston, C. W.

AU - Eusebi, V.

AU - Faverly, D.

AU - Heikkila, P.

AU - Holland, R.

AU - Kerner, H.

AU - Kulka, J.

AU - Jacquemier, J.

AU - Lacerda, M.

AU - Martinez-Penuela, J.

AU - De Miguel, C.

AU - Peterse, J. L.

AU - Rank, F.

AU - Regitnig, P.

AU - Reiner, A.

AU - Sapino, A.

AU - Sigal-Zafrani, B.

AU - Tanous, A. M.

AU - Thorstenson, S.

AU - Zozaya, E.

AU - Wells, C. A.

PY - 2003/8

Y1 - 2003/8

N2 - Controversies and inconsistencies regarding the pathological work-up of sentinel lymph nodes (SNs) led the European Working Group for Breast Screening Pathology (EWGBSP) to review published data and current evidence that can promote the formulation of European guidelines for the pathological work-up of SNs. After an evaluation of the accuracy of SN biopsy as a staging procedure, the yields of different sectioning methods and the immunohistochemical detection of metastatic cells are reviewed. Currently published data do not allow the significance of micrometastases or isolated tumour cells to be established, but it is suggested that approximately 18% of the cases may be associated with further nodal (non-SN) metastases, i.e. approximately 2% of all patients initially staged by SN biopsy. The methods for the intraoperative and molecular assessment of SNs are also surveyed.

AB - Controversies and inconsistencies regarding the pathological work-up of sentinel lymph nodes (SNs) led the European Working Group for Breast Screening Pathology (EWGBSP) to review published data and current evidence that can promote the formulation of European guidelines for the pathological work-up of SNs. After an evaluation of the accuracy of SN biopsy as a staging procedure, the yields of different sectioning methods and the immunohistochemical detection of metastatic cells are reviewed. Currently published data do not allow the significance of micrometastases or isolated tumour cells to be established, but it is suggested that approximately 18% of the cases may be associated with further nodal (non-SN) metastases, i.e. approximately 2% of all patients initially staged by SN biopsy. The methods for the intraoperative and molecular assessment of SNs are also surveyed.

KW - Breast cancer

KW - Frozen section

KW - Intraoperative cytology

KW - Isolated tumour cell

KW - Micrometastasis

KW - Molecular analysis

KW - Non-sentinel node metastasis

KW - Occult metastasis

KW - Sentinel lymph nodes

KW - Survival

UR - https://www.scopus.com/pages/publications/0041346050

U2 - 10.1016/S0959-8049(03)00203-X

DO - 10.1016/S0959-8049(03)00203-X

M3 - Review article

C2 - 12888359

AN - SCOPUS:0041346050

SN - 0959-8049

VL - 39

SP - 1654

EP - 1667

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 12

ER -

Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines

Abstract

UN SDGs

Keywords

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