Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma Factor σB in staphylococcus epidermidis

John J. Cotter; James P. O'Gara; Dietrich Mack; Eoin Casey

doi:10.1128/AEM.00261-08

Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma Factor σ^B in staphylococcus epidermidis

John J. Cotter, James P. O'Gara, Dietrich Mack, Eoin Casey

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

39 Citations (Scopus)

Abstract

Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of σ^B. Under anaerobic conditions, increased σ^B activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.

Original language	English
Pages (from-to)	261-264
Number of pages	4
Journal	Applied and Environmental Microbiology
Volume	75
Issue number	1
DOIs	https://doi.org/10.1128/AEM.00261-08
Publication status	Published - Jan 2009
Externally published	Yes

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title = "Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma Factor σB in staphylococcus epidermidis",

abstract = "Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of σB. Under anaerobic conditions, increased σB activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.",

author = "Cotter, \{John J.\} and O'Gara, \{James P.\} and Dietrich Mack and Eoin Casey",

year = "2009",

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AU - Mack, Dietrich

AU - Casey, Eoin

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AB - Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of σB. Under anaerobic conditions, increased σB activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.

UR - https://www.scopus.com/pages/publications/58149343974

U2 - 10.1128/AEM.00261-08

DO - 10.1128/AEM.00261-08

M3 - Article

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EP - 264

JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

IS - 1

ER -

Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma Factor σ^B in staphylococcus epidermidis

Abstract

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