OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(- -) mice aortas

Afshin Samali; Aideen O'Doherty; Timothy O'Brien

doi:10.1016/j.bbrc.2007.03.027

OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(- -) mice aortas

University of Galway
University of Helsinki
University Hospital MAS

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

5 Citations (Scopus)

Abstract

Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(- -) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved.

Original language	English (Ireland)
Pages (from-to)	681-686
Number of pages	6
Journal	Biochemical And Biophysical Research Communications
Volume	356
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2007.03.027
Publication status	Published - 1 May 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apolipoprotein E
Cell death
Gene expression
OxLDL
Oxidative stress
Smooth muscle cell

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Reeve, JLV,Stenson-Cox, C,O'Doherty, A,Porn-Ares, I,Ares, M,O'Brien, T,Samali, A
Reeve JL, Stenson-Cox C, O'Doherty A, PÃ¶rn-Ares I, Ares M, O'Brien T, Samali A

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10.1016/j.bbrc.2007.03.027

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title = "OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(- -) mice aortas",

abstract = "Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(- -) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved.",

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year = "2007",

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volume = "356",

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T1 - OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(- -) mice aortas

AU - Samali, Afshin

AU - O'Doherty, Aideen

AU - O'Brien, Timothy

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(- -) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved.

AB - Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(- -) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved.

KW - Apolipoprotein E

KW - Cell death

KW - Gene expression

KW - OxLDL

KW - Oxidative stress

KW - Smooth muscle cell

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U2 - 10.1016/j.bbrc.2007.03.027

DO - 10.1016/j.bbrc.2007.03.027

M3 - Article

VL - 356

SP - 681

EP - 686

JO - Biochemical And Biophysical Research Communications

JF - Biochemical And Biophysical Research Communications

IS - 3

ER -

OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(- -) mice aortas

Abstract

UN SDGs

Keywords

Authors (Note for portal: view the doc link for the full list of authors)

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