Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

Susan M. Rowe; Sorcha J. Coughlan; Neil J. McKenna; Elaine Garrett; Dirk G. Kieback; Desmond N. Carney; Denis R. Headon

Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

Susan M. Rowe
, Sorcha J. Coughlan
, Neil J. McKenna
, Elaine Garrett
, Dirk G. Kieback
, Desmond N. Carney
, Denis R. Headon

Molecular Biosciences

University of Galway
Baylor College of Medicine
Mater Misericordiae University Hospital

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

113 Citations (Scopus)

Abstract

Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (~300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.

Original language	English
Pages (from-to)	2743-2745
Number of pages	3
Journal	Cancer Research
Volume	55
Issue number	13
Publication status	Published - 1 Jul 1995

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SDG 3 Good Health and Well-being

Cite this

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title = "Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion",

abstract = "Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (\textasciitilde{}300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.",

author = "Rowe, \{Susan M.\} and Coughlan, \{Sorcha J.\} and McKenna, \{Neil J.\} and Elaine Garrett and Kieback, \{Dirk G.\} and Carney, \{Desmond N.\} and Headon, \{Denis R.\}",

year = "1995",

month = jul,

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language = "English",

volume = "55",

pages = "2743--2745",

journal = "Cancer Research",

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publisher = "American Association for Cancer Research Inc.",

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Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion. / Rowe, Susan M.; Coughlan, Sorcha J.; McKenna, Neil J. et al.
In: Cancer Research, Vol. 55, No. 13, 01.07.1995, p. 2743-2745.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

AU - Rowe, Susan M.

AU - Coughlan, Sorcha J.

AU - McKenna, Neil J.

AU - Garrett, Elaine

AU - Kieback, Dirk G.

AU - Carney, Desmond N.

AU - Headon, Denis R.

PY - 1995/7/1

Y1 - 1995/7/1

N2 - Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (~300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.

AB - Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (~300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.

UR - https://www.scopus.com/pages/publications/0029041961

M3 - Article

C2 - 7796397

AN - SCOPUS:0029041961

SN - 0008-5472

VL - 55

SP - 2743

EP - 2745

JO - Cancer Research

JF - Cancer Research

IS - 13

ER -

Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

Abstract

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