Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

Susan M. Rowe; Sorcha J. Coughlan; Neil J. McKenna; Elaine Garrett; Dirk G. Kieback; Desmond N. Carney; Denis R. Headon

Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

Susan M. Rowe, Sorcha J. Coughlan, Neil J. McKenna, Elaine Garrett, Dirk G. Kieback, Desmond N. Carney, Denis R. Headon

Molecular Biosciences

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

113 Citations (Scopus)

Abstract

Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (~300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.

Original language	English
Pages (from-to)	2743-2745
Number of pages	3
Journal	Cancer Research
Volume	55
Issue number	13
Publication status	Published - 1 Jul 1995

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Cite this

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title = "Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion",

abstract = "Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (\textasciitilde{}300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.",

author = "Rowe, \{Susan M.\} and Coughlan, \{Sorcha J.\} and McKenna, \{Neil J.\} and Elaine Garrett and Kieback, \{Dirk G.\} and Carney, \{Desmond N.\} and Headon, \{Denis R.\}",

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Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion. / Rowe, Susan M.; Coughlan, Sorcha J.; McKenna, Neil J. et al.
In: Cancer Research, Vol. 55, No. 13, 01.07.1995, p. 2743-2745.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

AU - Rowe, Susan M.

AU - Coughlan, Sorcha J.

AU - McKenna, Neil J.

AU - Garrett, Elaine

AU - Kieback, Dirk G.

AU - Carney, Desmond N.

AU - Headon, Denis R.

PY - 1995/7/1

Y1 - 1995/7/1

N2 - Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (~300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.

AB - Alu sequences, short, repetitive transposable DNA elements, are factors in a number of genetic diseases. We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gene, that showed an association with the incidence of sporadic ovarian carcinoma. Furthermore, the polymorphism was characterized as a small (~300-bp) insertion that was inherited in a Mendelian fashion. Because of its insertional character, we named this polymorphism PROGINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.

UR - https://www.scopus.com/pages/publications/0029041961

M3 - Article

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AN - SCOPUS:0029041961

SN - 0008-5472

VL - 55

SP - 2743

EP - 2745

JO - Cancer Research

JF - Cancer Research

IS - 13

ER -

Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

Abstract

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