OrbusNeich fully absorbable coronary stent platform incorporating dual partitioned coatings

Robert J. Cottone; G. Lawrence Thatcher; Sherry P. Parker; Laurence Hanks; David A. Kujawa; Stephen M. Rowland; Marco Costa; Robert S. Schwartz; Yoshinobu Onuma

doi:10.4244/eijv5ifa11

OrbusNeich fully absorbable coronary stent platform incorporating dual partitioned coatings

Robert J. Cottone, G. Lawrence Thatcher, Sherry P. Parker, Laurence Hanks, David A. Kujawa, Stephen M. Rowland, Marco Costa, Robert S. Schwartz, Yoshinobu Onuma

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

21 Citations (Scopus)

Abstract

The field of stent based tissue engineering continues to revolutionise modern medicine by designing novel materials to restore vascular tissue function. Accordingly, the following discussion examines a novel, absorbable, polymeric scaffold engineered in combination with dual therapeutic coating, enabling locally administered temporary scaffolding in the coronary arteries for long term vascular patency and repair. This coronary stent platform consists of an absorbable polymeric material stent structure that incorporates a dual partitioned coating, by means of pro-healing EPC (endothelial progenitor cell) capture technology allowing for rapid endothelial coverage, and an absorbable polymer matrix with sustained elution of sirolimus, a drug controlling neointimal proliferation. This paper provides a brief overview of the various innovations developed by OrbusNeich to create this fully absorbable coronary device platform.

Original language	English
Pages (from-to)	F65-F71
Journal	EuroIntervention
Volume	5
Issue number	SUPPL. F
DOIs	https://doi.org/10.4244/eijv5ifa11
Publication status	Published - Dec 2009
Externally published	Yes

Keywords

Absorbable polymer coronary stent
Bioabsorbable polymer coating
Drug eluting stent (DES)
Endothelial progenitor cell capture (EPC)
Genous™
Sirolimus

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10.4244/eijv5ifa11

Cite this

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title = "OrbusNeich fully absorbable coronary stent platform incorporating dual partitioned coatings",

abstract = "The field of stent based tissue engineering continues to revolutionise modern medicine by designing novel materials to restore vascular tissue function. Accordingly, the following discussion examines a novel, absorbable, polymeric scaffold engineered in combination with dual therapeutic coating, enabling locally administered temporary scaffolding in the coronary arteries for long term vascular patency and repair. This coronary stent platform consists of an absorbable polymeric material stent structure that incorporates a dual partitioned coating, by means of pro-healing EPC (endothelial progenitor cell) capture technology allowing for rapid endothelial coverage, and an absorbable polymer matrix with sustained elution of sirolimus, a drug controlling neointimal proliferation. This paper provides a brief overview of the various innovations developed by OrbusNeich to create this fully absorbable coronary device platform.",

keywords = "Absorbable polymer coronary stent, Bioabsorbable polymer coating, Drug eluting stent (DES), Endothelial progenitor cell capture (EPC), Genous{\texttrademark}, Sirolimus",

author = "Cottone, \{Robert J.\} and Thatcher, \{G. Lawrence\} and Parker, \{Sherry P.\} and Laurence Hanks and Kujawa, \{David A.\} and Rowland, \{Stephen M.\} and Marco Costa and Schwartz, \{Robert S.\} and Yoshinobu Onuma",

year = "2009",

month = dec,

doi = "10.4244/eijv5ifa11",

language = "English",

volume = "5",

pages = "F65--F71",

journal = "EuroIntervention",

issn = "1774-024X",

publisher = "Europa Group",

number = "SUPPL. F",

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T1 - OrbusNeich fully absorbable coronary stent platform incorporating dual partitioned coatings

AU - Cottone, Robert J.

AU - Thatcher, G. Lawrence

AU - Parker, Sherry P.

AU - Hanks, Laurence

AU - Kujawa, David A.

AU - Rowland, Stephen M.

AU - Costa, Marco

AU - Schwartz, Robert S.

AU - Onuma, Yoshinobu

PY - 2009/12

Y1 - 2009/12

N2 - The field of stent based tissue engineering continues to revolutionise modern medicine by designing novel materials to restore vascular tissue function. Accordingly, the following discussion examines a novel, absorbable, polymeric scaffold engineered in combination with dual therapeutic coating, enabling locally administered temporary scaffolding in the coronary arteries for long term vascular patency and repair. This coronary stent platform consists of an absorbable polymeric material stent structure that incorporates a dual partitioned coating, by means of pro-healing EPC (endothelial progenitor cell) capture technology allowing for rapid endothelial coverage, and an absorbable polymer matrix with sustained elution of sirolimus, a drug controlling neointimal proliferation. This paper provides a brief overview of the various innovations developed by OrbusNeich to create this fully absorbable coronary device platform.

AB - The field of stent based tissue engineering continues to revolutionise modern medicine by designing novel materials to restore vascular tissue function. Accordingly, the following discussion examines a novel, absorbable, polymeric scaffold engineered in combination with dual therapeutic coating, enabling locally administered temporary scaffolding in the coronary arteries for long term vascular patency and repair. This coronary stent platform consists of an absorbable polymeric material stent structure that incorporates a dual partitioned coating, by means of pro-healing EPC (endothelial progenitor cell) capture technology allowing for rapid endothelial coverage, and an absorbable polymer matrix with sustained elution of sirolimus, a drug controlling neointimal proliferation. This paper provides a brief overview of the various innovations developed by OrbusNeich to create this fully absorbable coronary device platform.

KW - Absorbable polymer coronary stent

KW - Bioabsorbable polymer coating

KW - Drug eluting stent (DES)

KW - Endothelial progenitor cell capture (EPC)

KW - Genous™

KW - Sirolimus

UR - https://www.scopus.com/pages/publications/77956150805

U2 - 10.4244/eijv5ifa11

DO - 10.4244/eijv5ifa11

M3 - Review article

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AN - SCOPUS:77956150805

SN - 1774-024X

VL - 5

SP - F65-F71

JO - EuroIntervention

JF - EuroIntervention

IS - SUPPL. F

ER -

OrbusNeich fully absorbable coronary stent platform incorporating dual partitioned coatings

Abstract

Keywords

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