NUIG4: A biocompatible pcu metalorganic framework with an exceptional doxorubicin encapsulation capacity: A biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity

Amir Abdo; Pau Farras; Constantina Papatriantafyllopoulou

doi:10.1039/D1TB02176A

NUIG4: A biocompatible pcu metalorganic framework with an exceptional doxorubicin encapsulation capacity: A biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity

Amir Abdo, Pau Farras, Constantina Papatriantafyllopoulou

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

7 Citations (Scopus)

Abstract

Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4O(CBAB)3]n (NUIG4), where CBABH2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m2 g-1 and high selectivity of 2.75 for C2H2 over CO2.

Original language	English (Ireland)
Pages (from-to)	1378-1385
Number of pages	8
Journal	Journal Of Materials Chemistry B
Volume	10
Issue number	9
DOIs	https://doi.org/10.1039/D1TB02176A
Publication status	Published - 1 Jan 2022

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Ahmed Ahmed, Constantinos G. Efthymiou, Rana Sanii, Ewa Patyk-Kazmiercza, Amir M. Alsharabasy, Meghan Winterlich, Naveen Kumar, Debobroto Sensharma, Wenming Tong, Sarah Guerin, Pau Farras, Sarah Hudson, Damien Thompson, Michael J. Zaworotko, Anastasios J. Tasiopoulos and Constantina Papatriantafyllopoulou
Ahmed, Ahmed and Efthymiou, Constantinos G. and Sanii, Rana and Patyk-Kazmierczak, Ewa and Alsharabasy, Amir M. and Winterlich, Meghan and Kumar, Naveen and Sensharma, Debobroto and Tong, Wenming and Guerin, Sarah and Farras, Pau and Hudson, Sarah and Thompson, Damien and Zaworotko, Michael J. and Tasiopoulos, Anastasios J. and Papatriantafyllopoulou, Constantina
A. Ahmed, C.G. Efthymiou, R. Sanii, E. Patyk-Kazmierczak, M. Winterlich, N. Kumar, D. Sensharma, W. Tong, S. Guerin, P. Farras, S. Hudson, D. Thompson, M.J. Zaworotko, A.J. Tasiopoulos, C. Papatriantafyllopoulou

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title = "NUIG4: A biocompatible pcu metalorganic framework with an exceptional doxorubicin encapsulation capacity: A biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity",

abstract = "Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4O(CBAB)3]n (NUIG4), where CBABH2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m2 g-1 and high selectivity of 2.75 for C2H2 over CO2.",

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NUIG4: A biocompatible pcu metalorganic framework with an exceptional doxorubicin encapsulation capacity: A biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity. / Abdo, Amir ; Farras, Pau ; Papatriantafyllopoulou, Constantina.
In: Journal Of Materials Chemistry B, Vol. 10, No. 9, 01.01.2022, p. 1378-1385.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

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AB - Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4O(CBAB)3]n (NUIG4), where CBABH2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m2 g-1 and high selectivity of 2.75 for C2H2 over CO2.

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NUIG4: A biocompatible pcu metalorganic framework with an exceptional doxorubicin encapsulation capacity: A biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity

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