Novel variation in the FABP3 promoter and its association with fatness traits in pigs

T. Sweeney; A. M. O'Halloran; R. M. Hamill; G. C. Davey; M. Gil; O. I. Southwood; M. T. Ryan

doi:10.1016/j.meatsci.2014.09.014

Novel variation in the FABP3 promoter and its association with fatness traits in pigs

T. Sweeney, A. M. O'Halloran, R. M. Hamill, G. C. Davey, M. Gil, O. I. Southwood, M. T. Ryan

Molecular Biosciences

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

10 Citations (Scopus)

Abstract

This study examines associations between SNPs in the promoter region of the fatty acid binding protein 3 (. FABP3) gene and fatness traits in pure bred Large White (n. =. 98), Duroc (n. =. 99) and Pietrain (n. =. 98) populations. In the Large White breed, SNP g.-634 C>A was associated a 27% increase in IMF (%) in the heterozygote (CA) and a 38% increase in the homozygote (CC) relative to the (AA) genotype in the M. semimembranosus (SM) muscle (. P=. 0.02). While the associations observed in this breed were suggestive of significance in both the SM and in the M. longissimus thoracis et lumborum (LTL) (. P=. 0.08), these associations no longer attained significance at thresholds adjusted for multiple testing. In conclusion, SNPs in the FABP3 promoter may contribute to IMF without influencing carcass fatness traits in pigs, however further confirmation of these associations in larger independent populations would be essential before their incorporation into breeding programmes.

Original language	English
Pages (from-to)	32-40
Number of pages	9
Journal	Meat Science
Volume	100
DOIs	https://doi.org/10.1016/j.meatsci.2014.09.014
Publication status	Published - 1 Feb 2015

Keywords

Carcass
Duroc
Fatty acid binding protein
Intramuscular fat
Large White
Pietrain

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10.1016/j.meatsci.2014.09.014

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@article{53f992610c9b44229dafee117d74910e,

title = "Novel variation in the FABP3 promoter and its association with fatness traits in pigs",

abstract = "This study examines associations between SNPs in the promoter region of the fatty acid binding protein 3 (. FABP3) gene and fatness traits in pure bred Large White (n. =. 98), Duroc (n. =. 99) and Pietrain (n. =. 98) populations. In the Large White breed, SNP g.-634 C>A was associated a 27\% increase in IMF (\%) in the heterozygote (CA) and a 38\% increase in the homozygote (CC) relative to the (AA) genotype in the M. semimembranosus (SM) muscle (. P=. 0.02). While the associations observed in this breed were suggestive of significance in both the SM and in the M. longissimus thoracis et lumborum (LTL) (. P=. 0.08), these associations no longer attained significance at thresholds adjusted for multiple testing. In conclusion, SNPs in the FABP3 promoter may contribute to IMF without influencing carcass fatness traits in pigs, however further confirmation of these associations in larger independent populations would be essential before their incorporation into breeding programmes.",

keywords = "Carcass, Duroc, Fatty acid binding protein, Intramuscular fat, Large White, Pietrain",

author = "T. Sweeney and O'Halloran, \{A. M.\} and Hamill, \{R. M.\} and Davey, \{G. C.\} and M. Gil and Southwood, \{O. I.\} and Ryan, \{M. T.\}",

note = "Publisher Copyright: {\textcopyright} 2014.",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.meatsci.2014.09.014",

language = "English",

volume = "100",

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T1 - Novel variation in the FABP3 promoter and its association with fatness traits in pigs

AU - Sweeney, T.

AU - O'Halloran, A. M.

AU - Hamill, R. M.

AU - Davey, G. C.

AU - Gil, M.

AU - Southwood, O. I.

AU - Ryan, M. T.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - This study examines associations between SNPs in the promoter region of the fatty acid binding protein 3 (. FABP3) gene and fatness traits in pure bred Large White (n. =. 98), Duroc (n. =. 99) and Pietrain (n. =. 98) populations. In the Large White breed, SNP g.-634 C>A was associated a 27% increase in IMF (%) in the heterozygote (CA) and a 38% increase in the homozygote (CC) relative to the (AA) genotype in the M. semimembranosus (SM) muscle (. P=. 0.02). While the associations observed in this breed were suggestive of significance in both the SM and in the M. longissimus thoracis et lumborum (LTL) (. P=. 0.08), these associations no longer attained significance at thresholds adjusted for multiple testing. In conclusion, SNPs in the FABP3 promoter may contribute to IMF without influencing carcass fatness traits in pigs, however further confirmation of these associations in larger independent populations would be essential before their incorporation into breeding programmes.

AB - This study examines associations between SNPs in the promoter region of the fatty acid binding protein 3 (. FABP3) gene and fatness traits in pure bred Large White (n. =. 98), Duroc (n. =. 99) and Pietrain (n. =. 98) populations. In the Large White breed, SNP g.-634 C>A was associated a 27% increase in IMF (%) in the heterozygote (CA) and a 38% increase in the homozygote (CC) relative to the (AA) genotype in the M. semimembranosus (SM) muscle (. P=. 0.02). While the associations observed in this breed were suggestive of significance in both the SM and in the M. longissimus thoracis et lumborum (LTL) (. P=. 0.08), these associations no longer attained significance at thresholds adjusted for multiple testing. In conclusion, SNPs in the FABP3 promoter may contribute to IMF without influencing carcass fatness traits in pigs, however further confirmation of these associations in larger independent populations would be essential before their incorporation into breeding programmes.

KW - Carcass

KW - Duroc

KW - Fatty acid binding protein

KW - Intramuscular fat

KW - Large White

KW - Pietrain

UR - https://www.scopus.com/pages/publications/84907855898

U2 - 10.1016/j.meatsci.2014.09.014

DO - 10.1016/j.meatsci.2014.09.014

M3 - Article

C2 - 25306509

AN - SCOPUS:84907855898

SN - 0309-1740

VL - 100

SP - 32

EP - 40

JO - Meat Science

JF - Meat Science

ER -

Novel variation in the FABP3 promoter and its association with fatness traits in pigs

Abstract

Keywords

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