TY - JOUR
T1 - Nitrofurantoin-induced hepatotoxicity mediated by CD8+ T cells
AU - Kelly, Brendan D.
AU - Heneghan, Michael A.
AU - Bennani, Fadel
AU - Connolly, Charles E.
AU - O'Gorman, Thomas A.
PY - 1998/5
Y1 - 1998/5
N2 - Nitrofurantoin is a synthetic nitrofuran commonly used for the treatment and prophylaxis of urinary tract infections. We describe the case of a 75- yr-old woman who was taking nitrofurantoin as prophylaxis against recurrent urinary tract infections, and who subsequently developed pulmonary and hepatic toxicity. We postulate that a breakdown product of the drug or the drug itself complexed to an endogenous peptide is presented by the class I HLA antigen on the hepatocyte cell membrane, inducing cytotoxic T cell activation and subsequently, hepatocyte death.
AB - Nitrofurantoin is a synthetic nitrofuran commonly used for the treatment and prophylaxis of urinary tract infections. We describe the case of a 75- yr-old woman who was taking nitrofurantoin as prophylaxis against recurrent urinary tract infections, and who subsequently developed pulmonary and hepatic toxicity. We postulate that a breakdown product of the drug or the drug itself complexed to an endogenous peptide is presented by the class I HLA antigen on the hepatocyte cell membrane, inducing cytotoxic T cell activation and subsequently, hepatocyte death.
UR - https://www.scopus.com/pages/publications/0032081134
U2 - 10.1016/S0002-9270(98)00112-9
DO - 10.1016/S0002-9270(98)00112-9
M3 - Article
C2 - 9625135
AN - SCOPUS:0032081134
SN - 0002-9270
VL - 93
SP - 819
EP - 821
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 5
ER -