Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives

Leila Tabrizi; Patrick McArdle; Andrea Erxleben; Hossein Chiniforoshan

doi:10.1016/j.ejmech.2015.09.018

Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives

Leila Tabrizi, Patrick McArdle, Andrea Erxleben, Hossein Chiniforoshan

Cellular & Molecular Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

58 Citations (Scopus)

Abstract

Metal complexes of the type [Ni(LC)₂(X)₂], 1 and 2, [Co(LC)₂(X)₂], 3 and 4 (LC: lidocaine, X Combining double low line dca (dicyanamide), 1 and 3, X Combining double low line NCS^-, 2 and 4) have been synthesized and characterized. The geometries of 1-4 were confirmed by single crystal X-ray crystallography. The complexes are water soluble and stable in aqueous solution. The interaction of 1-4 with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) was investigated using UV-visible and fluorescence spectrophotometric methods. A gel electrophoresis assay demonstrated that the complexes cleave pUC19 plasmid DNA. The in vitro free radical scavenging, antimicrobial activity and cytotoxic potential of all the complexes were examined.

Original language	English
Article number	8115
Pages (from-to)	516-529
Number of pages	14
Journal	European Journal of Medicinal Chemistry
Volume	103
DOIs	https://doi.org/10.1016/j.ejmech.2015.09.018
Publication status	Published - 20 Oct 2015

Keywords

BSA binding
Cobalt(II) complexes
Cytotoxicity
DNA binding
DNA cleavage
Lidocaine
Nickel(II) complexes

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Tabrizi, L., McArdle, P., Erxleben, A., Chiniforoshan, H.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2015.09.018

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title = "Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives",

abstract = "Metal complexes of the type [Ni(LC)2(X)2], 1 and 2, [Co(LC)2(X)2], 3 and 4 (LC: lidocaine, X Combining double low line dca (dicyanamide), 1 and 3, X Combining double low line NCS-, 2 and 4) have been synthesized and characterized. The geometries of 1-4 were confirmed by single crystal X-ray crystallography. The complexes are water soluble and stable in aqueous solution. The interaction of 1-4 with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) was investigated using UV-visible and fluorescence spectrophotometric methods. A gel electrophoresis assay demonstrated that the complexes cleave pUC19 plasmid DNA. The in vitro free radical scavenging, antimicrobial activity and cytotoxic potential of all the complexes were examined.",

keywords = "BSA binding, Cobalt(II) complexes, Cytotoxicity, DNA binding, DNA cleavage, Lidocaine, Nickel(II) complexes",

author = "Leila Tabrizi and Patrick McArdle and Andrea Erxleben and Hossein Chiniforoshan",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Masson SAS.",

year = "2015",

month = oct,

day = "20",

doi = "10.1016/j.ejmech.2015.09.018",

language = "English",

volume = "103",

pages = "516--529",

journal = "European Journal of Medicinal Chemistry",

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publisher = "Elsevier Masson s.r.l.",

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TY - JOUR

T1 - Nickel(II) and cobalt(II) complexes of lidocaine

T2 - Synthesis, structure and comparative in vitro evaluations of biological perspectives

AU - Tabrizi, Leila

AU - McArdle, Patrick

AU - Erxleben, Andrea

AU - Chiniforoshan, Hossein

PY - 2015/10/20

Y1 - 2015/10/20

N2 - Metal complexes of the type [Ni(LC)2(X)2], 1 and 2, [Co(LC)2(X)2], 3 and 4 (LC: lidocaine, X Combining double low line dca (dicyanamide), 1 and 3, X Combining double low line NCS-, 2 and 4) have been synthesized and characterized. The geometries of 1-4 were confirmed by single crystal X-ray crystallography. The complexes are water soluble and stable in aqueous solution. The interaction of 1-4 with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) was investigated using UV-visible and fluorescence spectrophotometric methods. A gel electrophoresis assay demonstrated that the complexes cleave pUC19 plasmid DNA. The in vitro free radical scavenging, antimicrobial activity and cytotoxic potential of all the complexes were examined.

AB - Metal complexes of the type [Ni(LC)2(X)2], 1 and 2, [Co(LC)2(X)2], 3 and 4 (LC: lidocaine, X Combining double low line dca (dicyanamide), 1 and 3, X Combining double low line NCS-, 2 and 4) have been synthesized and characterized. The geometries of 1-4 were confirmed by single crystal X-ray crystallography. The complexes are water soluble and stable in aqueous solution. The interaction of 1-4 with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) was investigated using UV-visible and fluorescence spectrophotometric methods. A gel electrophoresis assay demonstrated that the complexes cleave pUC19 plasmid DNA. The in vitro free radical scavenging, antimicrobial activity and cytotoxic potential of all the complexes were examined.

KW - BSA binding

KW - Cobalt(II) complexes

KW - Cytotoxicity

KW - DNA binding

KW - DNA cleavage

KW - Lidocaine

KW - Nickel(II) complexes

UR - https://www.scopus.com/pages/publications/84942317062

U2 - 10.1016/j.ejmech.2015.09.018

DO - 10.1016/j.ejmech.2015.09.018

M3 - Article

SN - 0223-5234

VL - 103

SP - 516

EP - 529

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 8115

ER -

Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives

Abstract

Keywords

Authors (Note for portal: view the doc link for the full list of authors)

UN SDGs

Access to Document

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