Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Adam P. Douglas; Dwaine R. Vance; Elaine M. Kenny; Derek W. Morris; Alexander P. Maxwell; Amy Jayne McKnight

doi:10.1038/srep07379

Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Adam P. Douglas
, Dwaine R. Vance
, Elaine M. Kenny
, Derek W. Morris
, Alexander P. Maxwell
, Amy Jayne McKnight

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

14 Citations (Scopus)

Abstract

Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).

Original language	English
Article number	7379
Journal	Scientific Reports
Volume	4
DOIs	https://doi.org/10.1038/srep07379
Publication status	Published - 9 Dec 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/srep07379

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title = "Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population",

abstract = "Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).",

author = "Douglas, \{Adam P.\} and Vance, \{Dwaine R.\} and Kenny, \{Elaine M.\} and Morris, \{Derek W.\} and Maxwell, \{Alexander P.\} and McKnight, \{Amy Jayne\}",

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language = "English",

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journal = "Scientific Reports",

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T1 - Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

AU - Douglas, Adam P.

AU - Vance, Dwaine R.

AU - Kenny, Elaine M.

AU - Morris, Derek W.

AU - Maxwell, Alexander P.

AU - McKnight, Amy Jayne

PY - 2014/12/9

Y1 - 2014/12/9

N2 - Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).

AB - Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).

UR - https://www.scopus.com/pages/publications/84923256178

U2 - 10.1038/srep07379

DO - 10.1038/srep07379

M3 - Article

SN - 2045-2322

VL - 4

JO - Scientific Reports

JF - Scientific Reports

M1 - 7379

ER -

Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Abstract

UN SDGs

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