New insights into the endophenotypic status of cognition in bipolar disorder: Genetic modelling study of twins and siblings

A. Georgiades; F. Rijsdijk; Fergus Kane; I. Rebollo-Mesa; Sridevi Kalidindi; K. K. Schulze; D. Stahl; Muriel Walshe; B. J. Sahakian; Colm McDonald; M. H. Hall; R. M. Murray; Eugenia Kravariti

doi:10.13025/27340

New insights into the endophenotypic status of cognition in bipolar disorder: Genetic modelling study of twins and siblings

A. Georgiades
, F. Rijsdijk
, Fergus Kane
, I. Rebollo-Mesa
, Sridevi Kalidindi
, K. K. Schulze
, D. Stahl
, Muriel Walshe
, B. J. Sahakian
, Colm McDonald
, M. H. Hall
, R. M. Murray
, Eugenia Kravariti

Psychiatry

King's College London
National Institute for Health Research Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust
University of Cambridge
McLean Hospital
King's College London

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

17 Citations (Scopus)

Abstract

Background Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder. Aims To quantify the shared genetic variability between bipolar disorder and cognitive measures. Method Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder. Results Using a parsimonious AE model, verbal episodic and spatial working memory showed statistically significant genetic correlations with bipolar disorder (r_g = |0.23|-|0.27|), which lost statistical significance after covarying for affective symptoms. Using an ACE model, IQ and visual-spatial learning showed statistically significant genetic correlations with bipolar disorder (r_g = |0.51|-|1.00|), which remained significant after covarying for affective symptoms. Conclusions Verbal episodic and spatial working memory capture a modest fraction of the bipolar diathesis. IQ and visual-spatial learning may tap into genetic substrates of non-affective symptomatology in bipolar disorder.

Original language	English
Pages (from-to)	539-547
Number of pages	9
Journal	British Journal of Psychiatry
Volume	208
Issue number	6
DOIs	https://doi.org/10.13025/27340 https://doi.org/10.1192/bjp.bp.115.167239
Publication status	Published - Jun 2016

Keywords

1st-degree relatives
depression
discordant
Externally hosted open access publications with University of Galway authors
heritability
memory
premorbid iq
psychosis
risk
schizophrenia

Access to Document

10.13025/27340Licence: CC BY-NC-ND
10.1192/bjp.bp.115.167239

Cite this

Georgiades, A., Rijsdijk, F., Kane, F., Rebollo-Mesa, I., Kalidindi, S., Schulze, K. K., Stahl, D., Walshe, M., Sahakian, B. J., McDonald, C., Hall, M. H., Murray, R. M., & Kravariti, E. (2016). New insights into the endophenotypic status of cognition in bipolar disorder: Genetic modelling study of twins and siblings. British Journal of Psychiatry, 208(6), 539-547. https://doi.org/10.13025/27340, https://doi.org/10.1192/bjp.bp.115.167239

@article{7f5d431880ce4b8a8f5d4c662a7f6441,

title = "New insights into the endophenotypic status of cognition in bipolar disorder: Genetic modelling study of twins and siblings",

abstract = "Background Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder. Aims To quantify the shared genetic variability between bipolar disorder and cognitive measures. Method Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder. Results Using a parsimonious AE model, verbal episodic and spatial working memory showed statistically significant genetic correlations with bipolar disorder (rg = |0.23|-|0.27|), which lost statistical significance after covarying for affective symptoms. Using an ACE model, IQ and visual-spatial learning showed statistically significant genetic correlations with bipolar disorder (rg = |0.51|-|1.00|), which remained significant after covarying for affective symptoms. Conclusions Verbal episodic and spatial working memory capture a modest fraction of the bipolar diathesis. IQ and visual-spatial learning may tap into genetic substrates of non-affective symptomatology in bipolar disorder.",

keywords = "1st-degree relatives, depression, discordant, Externally hosted open access publications with University of Galway authors, heritability, memory, premorbid iq, psychosis, risk, schizophrenia",

author = "A. Georgiades and F. Rijsdijk and Fergus Kane and I. Rebollo-Mesa and Sridevi Kalidindi and Schulze, \{K. K.\} and D. Stahl and Muriel Walshe and Sahakian, \{B. J.\} and Colm McDonald and Hall, \{M. H.\} and Murray, \{R. M.\} and Eugenia Kravariti",

note = "Publisher Copyright: {\textcopyright} The Royal College of Psychiatrists 2016.",

year = "2016",

month = jun,

doi = "10.13025/27340",

language = "English",

volume = "208",

pages = "539--547",

journal = "British Journal of Psychiatry",

issn = "0007-1250",

publisher = "Cambridge University Press",

number = "6",

}

Georgiades, A, Rijsdijk, F, Kane, F, Rebollo-Mesa, I, Kalidindi, S, Schulze, KK, Stahl, D, Walshe, M, Sahakian, BJ, McDonald, C, Hall, MH, Murray, RM & Kravariti, E 2016, 'New insights into the endophenotypic status of cognition in bipolar disorder: Genetic modelling study of twins and siblings', British Journal of Psychiatry, vol. 208, no. 6, pp. 539-547. https://doi.org/10.13025/27340, https://doi.org/10.1192/bjp.bp.115.167239

TY - JOUR

T1 - New insights into the endophenotypic status of cognition in bipolar disorder

T2 - Genetic modelling study of twins and siblings

AU - Georgiades, A.

AU - Rijsdijk, F.

AU - Kane, Fergus

AU - Rebollo-Mesa, I.

AU - Kalidindi, Sridevi

AU - Schulze, K. K.

AU - Stahl, D.

AU - Walshe, Muriel

AU - Sahakian, B. J.

AU - McDonald, Colm

AU - Hall, M. H.

AU - Murray, R. M.

AU - Kravariti, Eugenia

N1 - Publisher Copyright: © The Royal College of Psychiatrists 2016.

PY - 2016/6

Y1 - 2016/6

N2 - Background Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder. Aims To quantify the shared genetic variability between bipolar disorder and cognitive measures. Method Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder. Results Using a parsimonious AE model, verbal episodic and spatial working memory showed statistically significant genetic correlations with bipolar disorder (rg = |0.23|-|0.27|), which lost statistical significance after covarying for affective symptoms. Using an ACE model, IQ and visual-spatial learning showed statistically significant genetic correlations with bipolar disorder (rg = |0.51|-|1.00|), which remained significant after covarying for affective symptoms. Conclusions Verbal episodic and spatial working memory capture a modest fraction of the bipolar diathesis. IQ and visual-spatial learning may tap into genetic substrates of non-affective symptomatology in bipolar disorder.

AB - Background Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder. Aims To quantify the shared genetic variability between bipolar disorder and cognitive measures. Method Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder. Results Using a parsimonious AE model, verbal episodic and spatial working memory showed statistically significant genetic correlations with bipolar disorder (rg = |0.23|-|0.27|), which lost statistical significance after covarying for affective symptoms. Using an ACE model, IQ and visual-spatial learning showed statistically significant genetic correlations with bipolar disorder (rg = |0.51|-|1.00|), which remained significant after covarying for affective symptoms. Conclusions Verbal episodic and spatial working memory capture a modest fraction of the bipolar diathesis. IQ and visual-spatial learning may tap into genetic substrates of non-affective symptomatology in bipolar disorder.

KW - 1st-degree relatives

KW - depression

KW - discordant

KW - Externally hosted open access publications with University of Galway authors

KW - heritability

KW - memory

KW - premorbid iq

KW - psychosis

KW - risk

KW - schizophrenia

UR - http://hdl.handle.net/10379/11610

UR - https://www.scopus.com/pages/publications/84973460558

U2 - 10.13025/27340

DO - 10.13025/27340

M3 - Article

SN - 0007-1250

VL - 208

SP - 539

EP - 547

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - 6

ER -

New insights into the endophenotypic status of cognition in bipolar disorder: Genetic modelling study of twins and siblings

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this