Neuroanatomical Dysconnectivity Underlying Cognitive Deficits in Bipolar Disorder

Brian Hallahan; Colm Mcdonald; Denis O'Hora; Liam Kilmartin

doi:http://hdl.handle.net/10379/16009

Neuroanatomical Dysconnectivity Underlying Cognitive Deficits in Bipolar Disorder

Brian Hallahan, Colm Mcdonald, Denis O'Hora, Liam Kilmartin

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Abstract

BACKGROUND: Graph theory applied to brain networks is an emerging approach to understanding the brains topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder (BD) and recent reports of altered anatomical network organization, the association between connectivity and cognitive impairments in BD remains unclear.METHODS: We examined the role of anatomical network connectivity derived from Ti - and diffusion-weighted magnetic resonance imaging in impaired cognitive performance in individuals with BD (n = 32) compared with healthy control individuals (n = 38). Fractional anisotropy- and number of streamlines-weighted anatomical brain networks were generated by mapping constrained spherical deconvolution-reconstructed white matter among 86 cortical subcortical bilateral brain regions delineated in the individuals own coordinate space. Intelligence and executive function were investigated as distributed functions using measures of global, rich-club, and interhemispheric connectivity, while memory and social cognition were examined in relation to subnetwork connectivity.RESULTS: Lower executive functioning related to higher global clustering coefficient in participants with BD, and lower IQ performance may present with a differential relationship between global and interhemispheric efficiency in individuals with BD relative to control individuals. Spatial recognition memory accuracy and response times were similar between diagnostic groups and associated with basal ganglia and thalamus interconnectivity and connectivity within extended anatomical subnetworks in all participants. No anatomical subnetworks related to episodic memory, short-term memory, or social cognition generally or differently in BD.CONCLUSIONS: Results demonstrate selective influence of subnetwork patterns of connectivity in underlying cognitive performance generally and abnormal global topology underlying discrete cognitive impairments in BD.

Original language	English (Ireland)
Number of pages	11
Journal	Biological Psychiatry-Cognitive Neuroscience And Neuroimaging
Volume	5
DOIs	https://doi.org/http://hdl.handle.net/10379/16009
Publication status	Published - 1 Feb 2020

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Authors
McPhilemy, G,Nabulsi, L,Kilmartin, L,O'Hora, D,O'Donoghue, S,Tronchin, G,Costello, L,Najt, P,Ambati, S,Neilsen, G,Creighton, S,Byrne, F,McLoughlin, J,McDonald, C,Hallahan, B,Cannon, DM

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@article{e3eff35ba6d142b58308f36616241bba,

title = "Neuroanatomical Dysconnectivity Underlying Cognitive Deficits in Bipolar Disorder",

abstract = "BACKGROUND: Graph theory applied to brain networks is an emerging approach to understanding the brains topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder (BD) and recent reports of altered anatomical network organization, the association between connectivity and cognitive impairments in BD remains unclear.METHODS: We examined the role of anatomical network connectivity derived from Ti - and diffusion-weighted magnetic resonance imaging in impaired cognitive performance in individuals with BD (n = 32) compared with healthy control individuals (n = 38). Fractional anisotropy- and number of streamlines-weighted anatomical brain networks were generated by mapping constrained spherical deconvolution-reconstructed white matter among 86 cortical subcortical bilateral brain regions delineated in the individuals own coordinate space. Intelligence and executive function were investigated as distributed functions using measures of global, rich-club, and interhemispheric connectivity, while memory and social cognition were examined in relation to subnetwork connectivity.RESULTS: Lower executive functioning related to higher global clustering coefficient in participants with BD, and lower IQ performance may present with a differential relationship between global and interhemispheric efficiency in individuals with BD relative to control individuals. Spatial recognition memory accuracy and response times were similar between diagnostic groups and associated with basal ganglia and thalamus interconnectivity and connectivity within extended anatomical subnetworks in all participants. No anatomical subnetworks related to episodic memory, short-term memory, or social cognition generally or differently in BD.CONCLUSIONS: Results demonstrate selective influence of subnetwork patterns of connectivity in underlying cognitive performance generally and abnormal global topology underlying discrete cognitive impairments in BD.",

author = "Brian Hallahan and Colm Mcdonald and Denis O'Hora and Liam Kilmartin",

year = "2020",

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doi = "http://hdl.handle.net/10379/16009",

language = "English (Ireland)",

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journal = "Biological Psychiatry-Cognitive Neuroscience And Neuroimaging",

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T1 - Neuroanatomical Dysconnectivity Underlying Cognitive Deficits in Bipolar Disorder

AU - Hallahan, Brian

AU - Mcdonald, Colm

AU - O'Hora, Denis

AU - Kilmartin, Liam

PY - 2020/2/1

Y1 - 2020/2/1

N2 - BACKGROUND: Graph theory applied to brain networks is an emerging approach to understanding the brains topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder (BD) and recent reports of altered anatomical network organization, the association between connectivity and cognitive impairments in BD remains unclear.METHODS: We examined the role of anatomical network connectivity derived from Ti - and diffusion-weighted magnetic resonance imaging in impaired cognitive performance in individuals with BD (n = 32) compared with healthy control individuals (n = 38). Fractional anisotropy- and number of streamlines-weighted anatomical brain networks were generated by mapping constrained spherical deconvolution-reconstructed white matter among 86 cortical subcortical bilateral brain regions delineated in the individuals own coordinate space. Intelligence and executive function were investigated as distributed functions using measures of global, rich-club, and interhemispheric connectivity, while memory and social cognition were examined in relation to subnetwork connectivity.RESULTS: Lower executive functioning related to higher global clustering coefficient in participants with BD, and lower IQ performance may present with a differential relationship between global and interhemispheric efficiency in individuals with BD relative to control individuals. Spatial recognition memory accuracy and response times were similar between diagnostic groups and associated with basal ganglia and thalamus interconnectivity and connectivity within extended anatomical subnetworks in all participants. No anatomical subnetworks related to episodic memory, short-term memory, or social cognition generally or differently in BD.CONCLUSIONS: Results demonstrate selective influence of subnetwork patterns of connectivity in underlying cognitive performance generally and abnormal global topology underlying discrete cognitive impairments in BD.

AB - BACKGROUND: Graph theory applied to brain networks is an emerging approach to understanding the brains topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder (BD) and recent reports of altered anatomical network organization, the association between connectivity and cognitive impairments in BD remains unclear.METHODS: We examined the role of anatomical network connectivity derived from Ti - and diffusion-weighted magnetic resonance imaging in impaired cognitive performance in individuals with BD (n = 32) compared with healthy control individuals (n = 38). Fractional anisotropy- and number of streamlines-weighted anatomical brain networks were generated by mapping constrained spherical deconvolution-reconstructed white matter among 86 cortical subcortical bilateral brain regions delineated in the individuals own coordinate space. Intelligence and executive function were investigated as distributed functions using measures of global, rich-club, and interhemispheric connectivity, while memory and social cognition were examined in relation to subnetwork connectivity.RESULTS: Lower executive functioning related to higher global clustering coefficient in participants with BD, and lower IQ performance may present with a differential relationship between global and interhemispheric efficiency in individuals with BD relative to control individuals. Spatial recognition memory accuracy and response times were similar between diagnostic groups and associated with basal ganglia and thalamus interconnectivity and connectivity within extended anatomical subnetworks in all participants. No anatomical subnetworks related to episodic memory, short-term memory, or social cognition generally or differently in BD.CONCLUSIONS: Results demonstrate selective influence of subnetwork patterns of connectivity in underlying cognitive performance generally and abnormal global topology underlying discrete cognitive impairments in BD.

U2 - http://hdl.handle.net/10379/16009

DO - http://hdl.handle.net/10379/16009

M3 - Article

VL - 5

JO - Biological Psychiatry-Cognitive Neuroscience And Neuroimaging

JF - Biological Psychiatry-Cognitive Neuroscience And Neuroimaging

ER -

Neuroanatomical Dysconnectivity Underlying Cognitive Deficits in Bipolar Disorder

Abstract

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