NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS

Afshin Samali

doi:10.1111/j.1749-6632.2009.04725.x

NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS

Afshin Samali

Cellular & Molecular Medicine

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

Abstract

One strategy for cancer management consists of promoting selective apoptosis of cancer cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a proapoptotic cytokine, is a promising anticancer agent because of its ability to selectively induce apoptosis in established tumor cell lines but not in nontransformed cells. However, many tumors have developed mechanisms of resistance against killing by TRAIL. Whether or not the transcription factor nuclear factor (kappa B) is involved in TRAIL resistance is uncertain, and this short review aims to summarize currently available data on this question.

Original language	English (Ireland)
Title of host publication	Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?
Number of pages	12
Volume	1171
DOIs	https://doi.org/10.1111/j.1749-6632.2009.04725.x
Publication status	Published - 1 Sep 2009

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Plantivaux, A,Szegezdi, E,Samali, A,Egan, L

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10.1111/j.1749-6632.2009.04725.x

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title = "NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS",

abstract = "One strategy for cancer management consists of promoting selective apoptosis of cancer cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a proapoptotic cytokine, is a promising anticancer agent because of its ability to selectively induce apoptosis in established tumor cell lines but not in nontransformed cells. However, many tumors have developed mechanisms of resistance against killing by TRAIL. Whether or not the transcription factor nuclear factor (kappa B) is involved in TRAIL resistance is uncertain, and this short review aims to summarize currently available data on this question.",

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AB - One strategy for cancer management consists of promoting selective apoptosis of cancer cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a proapoptotic cytokine, is a promising anticancer agent because of its ability to selectively induce apoptosis in established tumor cell lines but not in nontransformed cells. However, many tumors have developed mechanisms of resistance against killing by TRAIL. Whether or not the transcription factor nuclear factor (kappa B) is involved in TRAIL resistance is uncertain, and this short review aims to summarize currently available data on this question.

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DO - 10.1111/j.1749-6632.2009.04725.x

M3 - Conference Publication

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BT - Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?

ER -

NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

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