Abstract
Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo.
| Original language | English (Ireland) |
|---|---|
| Article number | 272 |
| Journal | Cells |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Feb 2020 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- cancer therapy
- nanoparticle delivery
- tumor suppressor miRNA
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- O'Neill CP;Dwyer RM;
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