NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and Rho GTPases in cell migration.

Alanna Stanley; Kerry Thompson; Ailish Hynes

doi:10.1089/ars.2013.5713

NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and Rho GTPases in cell migration.

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Abstract

Rho GTPases are historically known to be central regulators of actin cytoskeleton reorganization. This affects many processes including cell migration. In addition, members of the Rac subfamily are known to be involved in reactive oxygen species (ROS) production through the regulation of NADPH oxidase (Nox) activity. This review focuses on relationships between Nox-regulated ROS, Rho GTPases, and cytoskeletal reorganization, in the context of cell migration.

Original language	English (Ireland)
Pages (from-to)	2026-2042
Number of pages	17
Journal	Antioxidants & Redox Signaling
Volume	20
Issue number	13
DOIs	https://doi.org/10.1089/ars.2013.5713
Publication status	Published - 1 May 2014

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Stanley A, Thompson K, Hynes A, Brakebusch C, Quondamatteo F

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10.1089/ars.2013.5713

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abstract = "Rho GTPases are historically known to be central regulators of actin cytoskeleton reorganization. This affects many processes including cell migration. In addition, members of the Rac subfamily are known to be involved in reactive oxygen species (ROS) production through the regulation of NADPH oxidase (Nox) activity. This review focuses on relationships between Nox-regulated ROS, Rho GTPases, and cytoskeletal reorganization, in the context of cell migration.",

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AB - Rho GTPases are historically known to be central regulators of actin cytoskeleton reorganization. This affects many processes including cell migration. In addition, members of the Rac subfamily are known to be involved in reactive oxygen species (ROS) production through the regulation of NADPH oxidase (Nox) activity. This review focuses on relationships between Nox-regulated ROS, Rho GTPases, and cytoskeletal reorganization, in the context of cell migration.

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NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and Rho GTPases in cell migration.

Abstract

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