N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells

Yunxue Zhao; Wenjia Liu; Ying Zhou; Xiumei Zhang; Paul V. Murphy

doi:10.1016/j.bmcl.2010.09.065

N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells

Yunxue Zhao
, Wenjia Liu
, Ying Zhou
, Xiumei Zhang
, Paul V. Murphy

Infectious Disease

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

28 Citations (Scopus)

Abstract

Previously N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin 1 has been shown to display properties associated with inhibition of angiogenesis. Here we examined the anti-tumourigenic role of 1 in a lung cancer cell line. This agent altered cell surface oligosaccharide expression and inhibited the growth of A549 cells by inducing G1 phase cell cycle arrest and apoptosis. Furthermore, stress fibre assembly and cell migration in A549 cells was markedly suppressed by 1.

Original language	English
Pages (from-to)	7540-7543
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2010.09.065
Publication status	Published - 15 Dec 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Cell cycle
Lung cancer
Migration
N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin
Stress fibre

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10.1016/j.bmcl.2010.09.065

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title = "N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells",

abstract = "Previously N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin 1 has been shown to display properties associated with inhibition of angiogenesis. Here we examined the anti-tumourigenic role of 1 in a lung cancer cell line. This agent altered cell surface oligosaccharide expression and inhibited the growth of A549 cells by inducing G1 phase cell cycle arrest and apoptosis. Furthermore, stress fibre assembly and cell migration in A549 cells was markedly suppressed by 1.",

keywords = "Apoptosis, Cell cycle, Lung cancer, Migration, N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin, Stress fibre",

author = "Yunxue Zhao and Wenjia Liu and Ying Zhou and Xiumei Zhang and Murphy, \{Paul V.\}",

year = "2010",

month = dec,

day = "15",

doi = "10.1016/j.bmcl.2010.09.065",

language = "English",

volume = "20",

pages = "7540--7543",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "24",

}

TY - JOUR

T1 - N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells

AU - Zhao, Yunxue

AU - Liu, Wenjia

AU - Zhou, Ying

AU - Zhang, Xiumei

AU - Murphy, Paul V.

PY - 2010/12/15

Y1 - 2010/12/15

N2 - Previously N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin 1 has been shown to display properties associated with inhibition of angiogenesis. Here we examined the anti-tumourigenic role of 1 in a lung cancer cell line. This agent altered cell surface oligosaccharide expression and inhibited the growth of A549 cells by inducing G1 phase cell cycle arrest and apoptosis. Furthermore, stress fibre assembly and cell migration in A549 cells was markedly suppressed by 1.

AB - Previously N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin 1 has been shown to display properties associated with inhibition of angiogenesis. Here we examined the anti-tumourigenic role of 1 in a lung cancer cell line. This agent altered cell surface oligosaccharide expression and inhibited the growth of A549 cells by inducing G1 phase cell cycle arrest and apoptosis. Furthermore, stress fibre assembly and cell migration in A549 cells was markedly suppressed by 1.

KW - Apoptosis

KW - Cell cycle

KW - Lung cancer

KW - Migration

KW - N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin

KW - Stress fibre

UR - https://www.scopus.com/pages/publications/78449296649

U2 - 10.1016/j.bmcl.2010.09.065

DO - 10.1016/j.bmcl.2010.09.065

M3 - Article

SN - 0960-894X

VL - 20

SP - 7540

EP - 7543

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells

Abstract

UN SDGs

Keywords

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