Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018)

Derek Morris

Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018)

Molecular Biosciences

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Abstract

Hill (Twin Research and Human Genetics, Vol. 21, , 84â88) presented a critique of our recently published paper in Cell Reports entitled âLarge-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targetsâ (Lam et al., Cell Reports, Vol. 21, 2017, 2597â). Specifically, Hill offered several interrelated comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG) (Turley et al., Nature Genetics, Vol. 50, , 229â237). In this brief article, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from âinflation in the FDR [false discovery rate]â, as suggested by Hill (Twin Research and Human Genetics, Vol. 21, , 84â88), and are not âmore relevant to the genetic contributions to education than they are to the genetic contributions to intelligenceâ.

Original language	English (Ireland)
Journal	Twin Research and Human Genetics
Volume	21
Issue number	5
Publication status	Published - 1 Jan 2018

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Lam, Max,Trampush, Joey W.,Yu, Jin,Knowles, Emma,Djurovic, Srdjan,Melle, Ingrid,Sundet, Kjetil,Christoforou, Andrea,Reinvang, Ivar,DeRosse, Pamela,Lundervold, Astri J.,Steen, Vidar M.,Espeseth, Thomas,RÃ¤ikkÃ¶nen, Katri,Widen, Elisabeth,Palotie, Aarno,Eriksson, Johan G.,Giegling, Ina,Konte, Bettina,Roussos, Panos,Giakoumaki, Stella,Burdick, Katherine E.,Payton, Antony,Ollier, William,Chiba-Falek, Ornit,Attix, Deborah K.,Need, Anna C.,Cirulli, Elizabeth T.,Voineskos, Aristotle N.,Stefanis, Nikos C.,Avramopoulos, Dimitrios,Hatzimanolis, Alex,Arking, Dan E.,Smyrnis, Nikolaos,Bilder, Robert M.,Freimer, Nelson A.,Cannon, Tyrone D.,London, Edythe,Poldrack, Russell A.,Sabb, Fred W.,Congdon, Eliza,Conley, Emily Drabant,Scult, Matthew A.,Dickinson, Dwight,Straub, Richard E.,Donohoe, Gary,Morris, Derek,Corvin, Aiden,Gill, Michael,Hariri, Ahmad R.,Weinberger, Daniel R.,Pendleton, Neil,Bitsios, Panos,Rujescu, Dan,Lahti, Jari,Hellard, Stephanie Le,Keller, Matthew C.,Andreassen, Ole A.,Lencz, Todd

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@article{ee40b3f460f942fc89dd4d5df945531a,

title = "Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018)",

abstract = "Hill (Twin Research and Human Genetics, Vol. 21, , 84{\^a}88) presented a critique of our recently published paper in Cell Reports entitled {\^a}Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets{\^a} (Lam et al., Cell Reports, Vol. 21, 2017, 2597{\^a}). Specifically, Hill offered several interrelated comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG) (Turley et al., Nature Genetics, Vol. 50, , 229{\^a}237). In this brief article, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from {\^a}inflation in the FDR [false discovery rate]{\^a}, as suggested by Hill (Twin Research and Human Genetics, Vol. 21, , 84{\^a}88), and are not {\^a}more relevant to the genetic contributions to education than they are to the genetic contributions to intelligence{\^a}.",

author = "Derek Morris",

year = "2018",

month = jan,

day = "1",

language = "English (Ireland)",

volume = "21",

journal = "Twin Research and Human Genetics",

number = "5",

}

TY - JOUR

T1 - Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018)

AU - Morris, Derek

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Hill (Twin Research and Human Genetics, Vol. 21, , 84â88) presented a critique of our recently published paper in Cell Reports entitled âLarge-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targetsâ (Lam et al., Cell Reports, Vol. 21, 2017, 2597â). Specifically, Hill offered several interrelated comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG) (Turley et al., Nature Genetics, Vol. 50, , 229â237). In this brief article, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from âinflation in the FDR [false discovery rate]â, as suggested by Hill (Twin Research and Human Genetics, Vol. 21, , 84â88), and are not âmore relevant to the genetic contributions to education than they are to the genetic contributions to intelligenceâ.

AB - Hill (Twin Research and Human Genetics, Vol. 21, , 84â88) presented a critique of our recently published paper in Cell Reports entitled âLarge-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targetsâ (Lam et al., Cell Reports, Vol. 21, 2017, 2597â). Specifically, Hill offered several interrelated comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG) (Turley et al., Nature Genetics, Vol. 50, , 229â237). In this brief article, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from âinflation in the FDR [false discovery rate]â, as suggested by Hill (Twin Research and Human Genetics, Vol. 21, , 84â88), and are not âmore relevant to the genetic contributions to education than they are to the genetic contributions to intelligenceâ.

M3 - Article

VL - 21

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

IS - 5

ER -

Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018)

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

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