Mucosal enzyme patterns in gastric epithelial disease

Phyllis A. Mooney; J. M. Walters; M. Little; F. M. Stevens; C. F. McCarthy

doi:10.1159/000198179

Mucosal enzyme patterns in gastric epithelial disease

Phyllis A. Mooney, J. M. Walters, M. Little, F. M. Stevens, C. F. McCarthy

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

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Abstract

A correlation was sought between changes in enzymes involved in gastric acid secretion (Mg-, NaK-, K-and HCO₃-stimulated ATPases) and histological changes in gastric biopsies. Alkaline phosphatase was also studied. Mg-and NaK-stimulated ATPase activities increased significantly in biopsies from the pylorus and antrum which showed moderate or severe gastritis. NaK ATPase levels increased and HCO₃ATPase decreased in incisural, body and fundic mucosa which had intestinal metaplasia and atrophic gastritis. No K⁺ATPase was found in normal mucosa. The total activity of alkaline phosphatase did not vary with histological changes in the gastric mucosa. Results indicate that the ATPase enzyme systems are sensitive indicators of gastric mucosal disease.

Original language	English
Pages (from-to)	6-15
Number of pages	10
Journal	Digestion
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1159/000198179
Publication status	Published - 1978

Keywords

Alkaline phosphatase
ATPase
Gastric mucosa
Gastritis
HCO<inf>3</inf>
Histology
Intestinal metaplasia
K ATPase
Mg ATPase
NaK ATPase

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title = "Mucosal enzyme patterns in gastric epithelial disease",

abstract = "A correlation was sought between changes in enzymes involved in gastric acid secretion (Mg-, NaK-, K-and HCO3-stimulated ATPases) and histological changes in gastric biopsies. Alkaline phosphatase was also studied. Mg-and NaK-stimulated ATPase activities increased significantly in biopsies from the pylorus and antrum which showed moderate or severe gastritis. NaK ATPase levels increased and HCO3ATPase decreased in incisural, body and fundic mucosa which had intestinal metaplasia and atrophic gastritis. No K+ATPase was found in normal mucosa. The total activity of alkaline phosphatase did not vary with histological changes in the gastric mucosa. Results indicate that the ATPase enzyme systems are sensitive indicators of gastric mucosal disease.",

keywords = "Alkaline phosphatase, ATPase, Gastric mucosa, Gastritis, HCO<inf>3</inf>, Histology, Intestinal metaplasia, K ATPase, Mg ATPase, NaK ATPase",

author = "Mooney, {Phyllis A.} and Walters, {J. M.} and M. Little and Stevens, {F. M.} and McCarthy, {C. F.}",

year = "1978",

doi = "10.1159/000198179",

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pages = "6--15",

journal = "Digestion",

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TY - JOUR

T1 - Mucosal enzyme patterns in gastric epithelial disease

AU - Mooney, Phyllis A.

AU - Walters, J. M.

AU - Little, M.

AU - Stevens, F. M.

AU - McCarthy, C. F.

PY - 1978

Y1 - 1978

N2 - A correlation was sought between changes in enzymes involved in gastric acid secretion (Mg-, NaK-, K-and HCO3-stimulated ATPases) and histological changes in gastric biopsies. Alkaline phosphatase was also studied. Mg-and NaK-stimulated ATPase activities increased significantly in biopsies from the pylorus and antrum which showed moderate or severe gastritis. NaK ATPase levels increased and HCO3ATPase decreased in incisural, body and fundic mucosa which had intestinal metaplasia and atrophic gastritis. No K+ATPase was found in normal mucosa. The total activity of alkaline phosphatase did not vary with histological changes in the gastric mucosa. Results indicate that the ATPase enzyme systems are sensitive indicators of gastric mucosal disease.

AB - A correlation was sought between changes in enzymes involved in gastric acid secretion (Mg-, NaK-, K-and HCO3-stimulated ATPases) and histological changes in gastric biopsies. Alkaline phosphatase was also studied. Mg-and NaK-stimulated ATPase activities increased significantly in biopsies from the pylorus and antrum which showed moderate or severe gastritis. NaK ATPase levels increased and HCO3ATPase decreased in incisural, body and fundic mucosa which had intestinal metaplasia and atrophic gastritis. No K+ATPase was found in normal mucosa. The total activity of alkaline phosphatase did not vary with histological changes in the gastric mucosa. Results indicate that the ATPase enzyme systems are sensitive indicators of gastric mucosal disease.

KW - Alkaline phosphatase

KW - ATPase

KW - Gastric mucosa

KW - Gastritis

KW - HCO<inf>3</inf>

KW - Histology

KW - Intestinal metaplasia

KW - K ATPase

KW - Mg ATPase

KW - NaK ATPase

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U2 - 10.1159/000198179

DO - 10.1159/000198179

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SN - 0012-2823

VL - 18

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EP - 15

JO - Digestion

JF - Digestion

IS - 1-2

ER -

Mucosal enzyme patterns in gastric epithelial disease

Abstract

Keywords

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