MRI characterization of in vitro clots at 3T and 7T: A technical note

Daniela Dumitriu LaGrange; Lijing Xin; François Lazeyras; Karen M. Doyle; Isabel Wanke; Karl Olof Lövblad

doi:10.1016/j.neurad.2023.06.003

MRI characterization of in vitro clots at 3T and 7T: A technical note

Daniela Dumitriu LaGrange
, Lijing Xin
, François Lazeyras
, Karen M. Doyle
, Isabel Wanke
, Karl Olof Lövblad

Physiology

University of Geneva
CIBM Center for Biomedical Imaging
School of Life Sciences
Klinik Hirslanden
Swiss Neuroradiology Institute
University Duisburg-Essen
Geneva University Hospitals

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

Abstract

In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ability of 3T and 7T MRI to distinguish the composition of in vitro clots, using quantitative T₁ and T₂*, alternatively R₂*, mapping. When comparing the two field strengths, we found a tradeoff between sensitivity for clot composition and confidence in the clot depiction associated with spatial resolution. The loss of sensitivity at 7T can be mitigated by combining the T₁ and T₂* signals.

Original language	English
Pages (from-to)	38-42
Number of pages	5
Journal	Journal of Neuroradiology
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.neurad.2023.06.003
Publication status	Published - Feb 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute ischemic stroke
Clot composition
Data acquisition
MRI

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10.1016/j.neurad.2023.06.003

Cite this

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title = "MRI characterization of in vitro clots at 3T and 7T: A technical note",

abstract = "In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ability of 3T and 7T MRI to distinguish the composition of in vitro clots, using quantitative T1 and T2*, alternatively R2*, mapping. When comparing the two field strengths, we found a tradeoff between sensitivity for clot composition and confidence in the clot depiction associated with spatial resolution. The loss of sensitivity at 7T can be mitigated by combining the T1 and T2* signals.",

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year = "2024",

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doi = "10.1016/j.neurad.2023.06.003",

language = "English",

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T1 - MRI characterization of in vitro clots at 3T and 7T

T2 - A technical note

AU - Dumitriu LaGrange, Daniela

AU - Xin, Lijing

AU - Lazeyras, François

AU - Doyle, Karen M.

AU - Wanke, Isabel

AU - Lövblad, Karl Olof

PY - 2024/2

Y1 - 2024/2

N2 - In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ability of 3T and 7T MRI to distinguish the composition of in vitro clots, using quantitative T1 and T2*, alternatively R2*, mapping. When comparing the two field strengths, we found a tradeoff between sensitivity for clot composition and confidence in the clot depiction associated with spatial resolution. The loss of sensitivity at 7T can be mitigated by combining the T1 and T2* signals.

AB - In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ability of 3T and 7T MRI to distinguish the composition of in vitro clots, using quantitative T1 and T2*, alternatively R2*, mapping. When comparing the two field strengths, we found a tradeoff between sensitivity for clot composition and confidence in the clot depiction associated with spatial resolution. The loss of sensitivity at 7T can be mitigated by combining the T1 and T2* signals.

KW - Acute ischemic stroke

KW - Clot composition

KW - Data acquisition

KW - MRI

UR - https://www.scopus.com/pages/publications/85163885689

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M3 - Article

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AN - SCOPUS:85163885689

SN - 0150-9861

VL - 51

SP - 38

EP - 42

JO - Journal of Neuroradiology

JF - Journal of Neuroradiology

IS - 1

ER -

MRI characterization of in vitro clots at 3T and 7T: A technical note

Abstract

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Keywords

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