Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4) 2·nH2O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine)

Andrea Erxleben; Susanne Metzger; James F. Britten; Colin J.L. Lock; Alberto Albinati; Bernhard Lippert

doi:10.1016/S0020-1693(02)00955-6

Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH₃)₂(1-MeC-N3)(9-EtGH-N7)](ClO₄) ₂·nH₂O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine)

Andrea Erxleben
, Susanne Metzger
, James F. Britten
, Colin J.L. Lock
, Alberto Albinati
, Bernhard Lippert

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

26 Citations (Scopus)

Abstract

The preparation, the crystal structure determination of two modifications, and the solution behavior of the mixed nucleobase complex trans-[Pt(NH₃)₂(1-MeC-N3)(9-EtGH-N7)](ClO₄) ₂·nH₂O (n=1.4 (2a) and 0 (2b)) with 1-MeC=1-methylcytosine and 9-EtGH=9-ethylguanine are reported. The compound is a model for the most abundant interstrand cross-link of trans-Pt(NH₃)₂Cl₂ (Transplatin) with double-stranded DNA. Characteristic features of this compound are the near-coplanarity of the two nucleobases and the intracomplex H bond between the exocyclic groups N(4)H₂ of 1-MeC and O(6) of 9-EtGH. Geometrical parameters responsible for the length of this H bond are studied. The compound can be considered a metal-modified Hoogsteen pair of cytosine and guanine. Its potential relevance to platinated DNA triplexes is also briefly discussed.

Original language	English
Pages (from-to)	461-469
Number of pages	9
Journal	Inorganica Chimica Acta
Volume	339
DOIs	https://doi.org/10.1016/S0020-1693(02)00955-6
Publication status	Published - 15 Nov 2002
Externally published	Yes

Keywords

Guanine complexes
H bonding
Mixed cytosine
Transplatin
X-ray crystallography

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Erxleben, A., Metzger, S., Britten, J. F., Lock, C. J. L., Albinati, A., & Lippert, B. (2002). Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH₃)₂(1-MeC-N3)(9-EtGH-N7)](ClO₄) ₂·nH₂O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine). Inorganica Chimica Acta, 339, 461-469. https://doi.org/10.1016/S0020-1693(02)00955-6

Erxleben, Andrea ; Metzger, Susanne ; Britten, James F. et al. / Model of the most abundant DNA interstrand cross-link of Transplatin : X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH₃)₂(1-MeC-N3)(9-EtGH-N7)](ClO₄) ₂·nH₂O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine). In: Inorganica Chimica Acta. 2002 ; Vol. 339. pp. 461-469.

@article{8ba0242152074e65ad53bef006190b4f,

title = "Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4) 2·nH2O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine)",

abstract = "The preparation, the crystal structure determination of two modifications, and the solution behavior of the mixed nucleobase complex trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4) 2·nH2O (n=1.4 (2a) and 0 (2b)) with 1-MeC=1-methylcytosine and 9-EtGH=9-ethylguanine are reported. The compound is a model for the most abundant interstrand cross-link of trans-Pt(NH3)2Cl2 (Transplatin) with double-stranded DNA. Characteristic features of this compound are the near-coplanarity of the two nucleobases and the intracomplex H bond between the exocyclic groups N(4)H2 of 1-MeC and O(6) of 9-EtGH. Geometrical parameters responsible for the length of this H bond are studied. The compound can be considered a metal-modified Hoogsteen pair of cytosine and guanine. Its potential relevance to platinated DNA triplexes is also briefly discussed.",

keywords = "Guanine complexes, H bonding, Mixed cytosine, Transplatin, X-ray crystallography",

author = "Andrea Erxleben and Susanne Metzger and Britten, \{James F.\} and Lock, \{Colin J.L.\} and Alberto Albinati and Bernhard Lippert",

year = "2002",

month = nov,

day = "15",

doi = "10.1016/S0020-1693(02)00955-6",

language = "English",

volume = "339",

pages = "461--469",

journal = "Inorganica Chimica Acta",

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Erxleben, A, Metzger, S, Britten, JF, Lock, CJL, Albinati, A & Lippert, B 2002, 'Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH₃)₂(1-MeC-N3)(9-EtGH-N7)](ClO₄) ₂·nH₂O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine)', Inorganica Chimica Acta, vol. 339, pp. 461-469. https://doi.org/10.1016/S0020-1693(02)00955-6

Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH₃)₂(1-MeC-N3)(9-EtGH-N7)](ClO₄) ₂·nH₂O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine). / Erxleben, Andrea; Metzger, Susanne; Britten, James F. et al.
In: Inorganica Chimica Acta, Vol. 339, 15.11.2002, p. 461-469.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - Model of the most abundant DNA interstrand cross-link of Transplatin

T2 - X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4) 2·nH2O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine)

AU - Erxleben, Andrea

AU - Metzger, Susanne

AU - Britten, James F.

AU - Lock, Colin J.L.

AU - Albinati, Alberto

AU - Lippert, Bernhard

PY - 2002/11/15

Y1 - 2002/11/15

N2 - The preparation, the crystal structure determination of two modifications, and the solution behavior of the mixed nucleobase complex trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4) 2·nH2O (n=1.4 (2a) and 0 (2b)) with 1-MeC=1-methylcytosine and 9-EtGH=9-ethylguanine are reported. The compound is a model for the most abundant interstrand cross-link of trans-Pt(NH3)2Cl2 (Transplatin) with double-stranded DNA. Characteristic features of this compound are the near-coplanarity of the two nucleobases and the intracomplex H bond between the exocyclic groups N(4)H2 of 1-MeC and O(6) of 9-EtGH. Geometrical parameters responsible for the length of this H bond are studied. The compound can be considered a metal-modified Hoogsteen pair of cytosine and guanine. Its potential relevance to platinated DNA triplexes is also briefly discussed.

AB - The preparation, the crystal structure determination of two modifications, and the solution behavior of the mixed nucleobase complex trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4) 2·nH2O (n=1.4 (2a) and 0 (2b)) with 1-MeC=1-methylcytosine and 9-EtGH=9-ethylguanine are reported. The compound is a model for the most abundant interstrand cross-link of trans-Pt(NH3)2Cl2 (Transplatin) with double-stranded DNA. Characteristic features of this compound are the near-coplanarity of the two nucleobases and the intracomplex H bond between the exocyclic groups N(4)H2 of 1-MeC and O(6) of 9-EtGH. Geometrical parameters responsible for the length of this H bond are studied. The compound can be considered a metal-modified Hoogsteen pair of cytosine and guanine. Its potential relevance to platinated DNA triplexes is also briefly discussed.

KW - Guanine complexes

KW - H bonding

KW - Mixed cytosine

KW - Transplatin

KW - X-ray crystallography

UR - https://www.scopus.com/pages/publications/0037112109

U2 - 10.1016/S0020-1693(02)00955-6

DO - 10.1016/S0020-1693(02)00955-6

M3 - Article

SN - 0020-1693

VL - 339

SP - 461

EP - 469

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Erxleben A, Metzger S, Britten JF, Lock CJL, Albinati A, Lippert B. Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH₃)₂(1-MeC-N3)(9-EtGH-N7)](ClO₄) ₂·nH₂O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine). Inorganica Chimica Acta. 2002 Nov 15;339:461-469. doi: 10.1016/S0020-1693(02)00955-6