Abstract
Alterations in at least six of the genes that encode proteins involved in the mismatch repair (MMR) system have been identified in either HNPCC or sporadic colon cancer. We aimed to analyse the proportion of patients with colorectal cancer with loss of immunostaining for MMR proteins in order to determine the feasibility of molecular screening for the loss of MMR proteins through the study of unselected patients with colorectal cancer.
| Original language | English (Ireland) |
|---|---|
| Pages (from-to) | 397-408 |
| Number of pages | 12 |
| Journal | Journal of gastrointestinal oncology |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Dec 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Colorectal cancer
- HNPCC
- Mismatch repair (MMR) proteins
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Kheirelseid EA, Miller N, Chang KH, Curran C, Hennessey E, Sheehan M, Kerin MJ
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