Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5,6-dihydro-5-azapurines

Alena I. Siutkina; Svetlana Kalinina; Rongfang Liu; Laura H. Heitman; Anna Junker; Constantin G. Daniliuc; Dmitrii V. Kalinin

doi:10.1021/acsomega.3c00765

Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5,6-dihydro-5-azapurines

Alena I. Siutkina
, Svetlana Kalinina
, Rongfang Liu
, Laura H. Heitman
, Anna Junker
, Constantin G. Daniliuc
, Dmitrii V. Kalinin

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

7 Citations (Scopus)

Abstract

We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The method is simple, fast, and relies on easily accessible reagents such as trimethyl orthoformate, acetic acid, and aminotriazole-derived N,N′-disubstituted formamidines. The preliminary biological evaluation revealed that selected representatives of synthesized 6-methoxy-5,6-dihydro-5-azapurines dose-dependently reduce the viability of HepG2 and A549 cancer cells having little to no influence on five tested purinergic receptors.

Original language	English
Pages (from-to)	14097-14112
Number of pages	16
Journal	ACS Omega
Volume	8
Issue number	15
DOIs	https://doi.org/10.1021/acsomega.3c00765
Publication status	Published - 18 Apr 2023
Externally published	Yes

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10.1021/acsomega.3c00765

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title = "Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5,6-dihydro-5-azapurines",

abstract = "We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The method is simple, fast, and relies on easily accessible reagents such as trimethyl orthoformate, acetic acid, and aminotriazole-derived N,N′-disubstituted formamidines. The preliminary biological evaluation revealed that selected representatives of synthesized 6-methoxy-5,6-dihydro-5-azapurines dose-dependently reduce the viability of HepG2 and A549 cancer cells having little to no influence on five tested purinergic receptors.",

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year = "2023",

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doi = "10.1021/acsomega.3c00765",

language = "English",

volume = "8",

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T1 - Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5,6-dihydro-5-azapurines

AU - Siutkina, Alena I.

AU - Kalinina, Svetlana

AU - Liu, Rongfang

AU - Heitman, Laura H.

AU - Junker, Anna

AU - Daniliuc, Constantin G.

AU - Kalinin, Dmitrii V.

PY - 2023/4/18

Y1 - 2023/4/18

N2 - We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The method is simple, fast, and relies on easily accessible reagents such as trimethyl orthoformate, acetic acid, and aminotriazole-derived N,N′-disubstituted formamidines. The preliminary biological evaluation revealed that selected representatives of synthesized 6-methoxy-5,6-dihydro-5-azapurines dose-dependently reduce the viability of HepG2 and A549 cancer cells having little to no influence on five tested purinergic receptors.

AB - We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The method is simple, fast, and relies on easily accessible reagents such as trimethyl orthoformate, acetic acid, and aminotriazole-derived N,N′-disubstituted formamidines. The preliminary biological evaluation revealed that selected representatives of synthesized 6-methoxy-5,6-dihydro-5-azapurines dose-dependently reduce the viability of HepG2 and A549 cancer cells having little to no influence on five tested purinergic receptors.

UR - https://www.scopus.com/pages/publications/85152199768

U2 - 10.1021/acsomega.3c00765

DO - 10.1021/acsomega.3c00765

M3 - Article

AN - SCOPUS:85152199768

SN - 2470-1343

VL - 8

SP - 14097

EP - 14112

JO - ACS Omega

JF - ACS Omega

IS - 15

ER -

Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5,6-dihydro-5-azapurines

Abstract

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