Microscopic gel-liquid interfaces supported by hollow microneedle array for voltammetric drug detection

Patricia Vazquez

Microscopic gel-liquid interfaces supported by hollow microneedle array for voltammetric drug detection

Patricia Vazquez

Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

Abstract

This report describes a method for integration of a gelâliquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAÎ¼Mâ1, a limit of detection of 50nM and a linear range between 50 and 200nM.

Original language	English (Ireland)
Journal	Sensors And Actuators B-Chemical
Volume	201
Publication status	Published - 1 Jan 2014

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Vazquez, Patricia,Herzog, Gregoire,O'Mahony, Conor,O'Brien, Joseph,Scully, James,Blake, Alan,O'Mathuna, Cian,Galvin, Paul

Cite this

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title = "Microscopic gel-liquid interfaces supported by hollow microneedle array for voltammetric drug detection",

abstract = "This report describes a method for integration of a gel{\^a}liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nA{\^I}¼M{\^a}1, a limit of detection of 50nM and a linear range between 50 and 200nM.",

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AB - This report describes a method for integration of a gelâliquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAÎ¼Mâ1, a limit of detection of 50nM and a linear range between 50 and 200nM.

M3 - Article

VL - 201

JO - Sensors And Actuators B-Chemical

JF - Sensors And Actuators B-Chemical

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Microscopic gel-liquid interfaces supported by hollow microneedle array for voltammetric drug detection

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

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