Microcavity array supported lipid bilayer models of ganglioside - influenza hemagglutinin1binding

Guilherme B. Berselli; Nirod Kumar Sarangi; Aurélien V. Gimenez; Paul V. Murphy; Tia E. Keyes

doi:10.1039/d0cc04276e

Microcavity array supported lipid bilayer models of ganglioside - influenza hemagglutinin₁binding

Guilherme B. Berselli, Nirod Kumar Sarangi, Aurélien V. Gimenez, Paul V. Murphy, Tia E. Keyes

Infectious Disease

Dublin City University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

12 Citations (Scopus)

Abstract

The binding of influenza receptor (HA₁) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA₁preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA₁GM1 or GM3.

Original language	English
Pages (from-to)	11251-11254
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	76
DOIs	https://doi.org/10.1039/d0cc04276e
Publication status	Published - 28 Sep 2020

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10.1039/d0cc04276e

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abstract = "The binding of influenza receptor (HA1) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA1preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA1GM1 or GM3.",

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AU - Berselli, Guilherme B.

AU - Sarangi, Nirod Kumar

AU - Gimenez, Aurélien V.

AU - Murphy, Paul V.

AU - Keyes, Tia E.

PY - 2020/9/28

Y1 - 2020/9/28

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AB - The binding of influenza receptor (HA1) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA1preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA1GM1 or GM3.

UR - https://www.scopus.com/pages/publications/85091587667

U2 - 10.1039/d0cc04276e

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SN - 1359-7345

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EP - 11254

JO - Chemical Communications

JF - Chemical Communications

IS - 76

ER -

Microcavity array supported lipid bilayer models of ganglioside - influenza hemagglutinin₁binding

Abstract

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