Microcavity array supported lipid bilayer models of ganglioside - influenza hemagglutinin1binding

Guilherme B. Berselli; Nirod Kumar Sarangi; Aurélien V. Gimenez; Paul V. Murphy; Tia E. Keyes

doi:10.13025/15041

Microcavity array supported lipid bilayer models of ganglioside - influenza hemagglutinin₁binding

Guilherme B. Berselli
, Nirod Kumar Sarangi
, Aurélien V. Gimenez
, Paul V. Murphy
, Tia E. Keyes

Infectious Disease

Dublin City University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

14 Citations (Scopus)

Abstract

The binding of influenza receptor (HA₁) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA₁preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA₁GM1 or GM3.

Original language	English
Pages (from-to)	11251-11254
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	76
DOIs	https://doi.org/10.13025/15041 https://doi.org/10.1039/d0cc04276e
Publication status	Published - 28 Sept 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

binding
cholesterol
domain
membrane
protein interactions
specificity
virus

Access to Document

10.13025/15041Licence: CC BY
10.1039/d0cc04276e

Bersellietal off templateAccepted author manuscript, 983 KBLicence: CC BY

Cite this

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abstract = "The binding of influenza receptor (HA1) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA1preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA1GM1 or GM3.",

keywords = "binding, cholesterol, domain, membrane, protein interactions, specificity, virus",

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AU - Berselli, Guilherme B.

AU - Sarangi, Nirod Kumar

AU - Gimenez, Aurélien V.

AU - Murphy, Paul V.

AU - Keyes, Tia E.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2020.

PY - 2020/9/28

Y1 - 2020/9/28

N2 - The binding of influenza receptor (HA1) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA1preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA1GM1 or GM3.

AB - The binding of influenza receptor (HA1) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA1preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA1GM1 or GM3.

KW - binding

KW - cholesterol

KW - domain

KW - membrane

KW - protein interactions

KW - specificity

KW - virus

UR - http://hdl.handle.net/10379/16442

UR - https://www.scopus.com/pages/publications/85091587667

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JF - Chemical Communications

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