Methyl-directed DNA mismatch repair in Escherichia coli

Robert S. Lahue; Paul Modrich

doi:10.1016/0027-5107(88)90037-1

Methyl-directed DNA mismatch repair in Escherichia coli

Robert S. Lahue, Paul Modrich

Duke University Medical Center

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

23 Citations (Scopus)

Abstract

Some of the molecular aspects of methyl-directed mismatch repair in E. coli have been characterized. These include: mismatch recognition by mutS protein in which different mispairs are bound with different affinities; the direct involvement of d(GATC) sites; and strand scission by mutH protein at d(GATC) sequences with strand selection based on methylation of the DNA at those sites. In addition, communication over a distance between a mismatch and d(GATC) sites has been implicated. Analysis of mismatch correlation in a defined system (Lahue et al., unpublished) should provide a direct means to further molecular aspects of this process.

Original language	English
Pages (from-to)	37-43
Number of pages	7
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	198
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(88)90037-1
Publication status	Published - Mar 1988
Externally published	Yes

Keywords

(E. coli)
DNA repair
Gene conversion
methyl-directed
Methylation of DNA
Mismatch repair

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10.1016/0027-5107(88)90037-1

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AB - Some of the molecular aspects of methyl-directed mismatch repair in E. coli have been characterized. These include: mismatch recognition by mutS protein in which different mispairs are bound with different affinities; the direct involvement of d(GATC) sites; and strand scission by mutH protein at d(GATC) sequences with strand selection based on methylation of the DNA at those sites. In addition, communication over a distance between a mismatch and d(GATC) sites has been implicated. Analysis of mismatch correlation in a defined system (Lahue et al., unpublished) should provide a direct means to further molecular aspects of this process.

KW - (E. coli)

KW - DNA repair

KW - Gene conversion

KW - methyl-directed

KW - Methylation of DNA

KW - Mismatch repair

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Methyl-directed DNA mismatch repair in Escherichia coli

Abstract

Keywords

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