TY - JOUR
T1 - Metal-modified nucleobase pairs involving 7,9-dimethylguanine
T2 - trans- a2Pt(II) analogues (a = NH3 or CH3NH2) of Watson-Crick GC and homo GG pairs
AU - Metzger, Susanne
AU - Erxleben, Andrea
AU - Lippert, Bernhard
PY - 1997/4
Y1 - 1997/4
N2 - The analogy between H-bonded nucleobase pairs and their metalated analogues is extended to the hemiprotonated pair of 7,9-dimethylguanine (7,9- DimeG) and the Watson-Crick and reversed Watson-Crick pair between 7,9- dimethylguaninium (7,9-DimeGH+) and 1-methylcytosine (1-MeC). The crystal structure analyses of two model compounds, trans-[Pt(CH3NH2)2(7,9-DimeG- NI)2](NO3)2 (1) and trans-[Pt(NH3)2(1-MeC-N3)(7,9-DimeG- NI)](PF6)2·2.5 H2O (3a) are reported. Pt binding is through N1 of 7,9- DimeG and N3 of 1-MeC. In solution, 3a exists in a mixture with Watson-Crick and reversed Watson-Crick arrangements of the two bases, depending on solvent, concentration and anions.
AB - The analogy between H-bonded nucleobase pairs and their metalated analogues is extended to the hemiprotonated pair of 7,9-dimethylguanine (7,9- DimeG) and the Watson-Crick and reversed Watson-Crick pair between 7,9- dimethylguaninium (7,9-DimeGH+) and 1-methylcytosine (1-MeC). The crystal structure analyses of two model compounds, trans-[Pt(CH3NH2)2(7,9-DimeG- NI)2](NO3)2 (1) and trans-[Pt(NH3)2(1-MeC-N3)(7,9-DimeG- NI)](PF6)2·2.5 H2O (3a) are reported. Pt binding is through N1 of 7,9- DimeG and N3 of 1-MeC. In solution, 3a exists in a mixture with Watson-Crick and reversed Watson-Crick arrangements of the two bases, depending on solvent, concentration and anions.
KW - 7,9-Dimethylguanine
KW - Metal-modified base pairs
KW - Pt complex
UR - https://www.scopus.com/pages/publications/0030948263
U2 - 10.1007/s007750050131
DO - 10.1007/s007750050131
M3 - Article
SN - 0949-8257
VL - 2
SP - 256
EP - 264
JO - Journal of Biological Inorganic Chemistry
JF - Journal of Biological Inorganic Chemistry
IS - 2
ER -