Metal-modified nucleobase pairs involving 7,9-dimethylguanine: trans- a2Pt(II) analogues (a = NH3 or CH3NH2) of Watson-Crick GC and homo GG pairs

Susanne Metzger; Andrea Erxleben; Bernhard Lippert

doi:10.1007/s007750050131

Metal-modified nucleobase pairs involving 7,9-dimethylguanine: trans- a₂Pt(II) analogues (a = NH₃ or CH₃NH₂) of Watson-Crick GC and homo GG pairs

Susanne Metzger
, Andrea Erxleben
, Bernhard Lippert

Technische Universität Dortmund

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

20 Citations (Scopus)

Abstract

The analogy between H-bonded nucleobase pairs and their metalated analogues is extended to the hemiprotonated pair of 7,9-dimethylguanine (7,9- DimeG) and the Watson-Crick and reversed Watson-Crick pair between 7,9- dimethylguaninium (7,9-DimeGH⁺) and 1-methylcytosine (1-MeC). The crystal structure analyses of two model compounds, trans-[Pt(CH₃NH₂)₂(7,9-DimeG- NI)₂](NO₃)₂ (1) and trans-[Pt(NH₃)₂(1-MeC-N3)(7,9-DimeG- NI)](PF₆)₂·2.5 H₂O (3a) are reported. Pt binding is through N1 of 7,9- DimeG and N3 of 1-MeC. In solution, 3a exists in a mixture with Watson-Crick and reversed Watson-Crick arrangements of the two bases, depending on solvent, concentration and anions.

Original language	English
Pages (from-to)	256-264
Number of pages	9
Journal	Journal of Biological Inorganic Chemistry
Volume	2
Issue number	2
DOIs	https://doi.org/10.1007/s007750050131
Publication status	Published - Apr 1997
Externally published	Yes

Keywords

7,9-Dimethylguanine
Metal-modified base pairs
Pt complex

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10.1007/s007750050131

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title = "Metal-modified nucleobase pairs involving 7,9-dimethylguanine: trans- a2Pt(II) analogues (a = NH3 or CH3NH2) of Watson-Crick GC and homo GG pairs",

abstract = "The analogy between H-bonded nucleobase pairs and their metalated analogues is extended to the hemiprotonated pair of 7,9-dimethylguanine (7,9- DimeG) and the Watson-Crick and reversed Watson-Crick pair between 7,9- dimethylguaninium (7,9-DimeGH+) and 1-methylcytosine (1-MeC). The crystal structure analyses of two model compounds, trans-[Pt(CH3NH2)2(7,9-DimeG- NI)2](NO3)2 (1) and trans-[Pt(NH3)2(1-MeC-N3)(7,9-DimeG- NI)](PF6)2·2.5 H2O (3a) are reported. Pt binding is through N1 of 7,9- DimeG and N3 of 1-MeC. In solution, 3a exists in a mixture with Watson-Crick and reversed Watson-Crick arrangements of the two bases, depending on solvent, concentration and anions.",

keywords = "7,9-Dimethylguanine, Metal-modified base pairs, Pt complex",

author = "Susanne Metzger and Andrea Erxleben and Bernhard Lippert",

year = "1997",

month = apr,

doi = "10.1007/s007750050131",

language = "English",

volume = "2",

pages = "256--264",

journal = "Journal of Biological Inorganic Chemistry",

issn = "0949-8257",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

Metal-modified nucleobase pairs involving 7,9-dimethylguanine: trans- a₂Pt(II) analogues (a = NH₃ or CH₃NH₂) of Watson-Crick GC and homo GG pairs. / Metzger, Susanne; Erxleben, Andrea; Lippert, Bernhard.
In: Journal of Biological Inorganic Chemistry, Vol. 2, No. 2, 04.1997, p. 256-264.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - Metal-modified nucleobase pairs involving 7,9-dimethylguanine

T2 - trans- a2Pt(II) analogues (a = NH3 or CH3NH2) of Watson-Crick GC and homo GG pairs

AU - Metzger, Susanne

AU - Erxleben, Andrea

AU - Lippert, Bernhard

PY - 1997/4

Y1 - 1997/4

N2 - The analogy between H-bonded nucleobase pairs and their metalated analogues is extended to the hemiprotonated pair of 7,9-dimethylguanine (7,9- DimeG) and the Watson-Crick and reversed Watson-Crick pair between 7,9- dimethylguaninium (7,9-DimeGH+) and 1-methylcytosine (1-MeC). The crystal structure analyses of two model compounds, trans-[Pt(CH3NH2)2(7,9-DimeG- NI)2](NO3)2 (1) and trans-[Pt(NH3)2(1-MeC-N3)(7,9-DimeG- NI)](PF6)2·2.5 H2O (3a) are reported. Pt binding is through N1 of 7,9- DimeG and N3 of 1-MeC. In solution, 3a exists in a mixture with Watson-Crick and reversed Watson-Crick arrangements of the two bases, depending on solvent, concentration and anions.

AB - The analogy between H-bonded nucleobase pairs and their metalated analogues is extended to the hemiprotonated pair of 7,9-dimethylguanine (7,9- DimeG) and the Watson-Crick and reversed Watson-Crick pair between 7,9- dimethylguaninium (7,9-DimeGH+) and 1-methylcytosine (1-MeC). The crystal structure analyses of two model compounds, trans-[Pt(CH3NH2)2(7,9-DimeG- NI)2](NO3)2 (1) and trans-[Pt(NH3)2(1-MeC-N3)(7,9-DimeG- NI)](PF6)2·2.5 H2O (3a) are reported. Pt binding is through N1 of 7,9- DimeG and N3 of 1-MeC. In solution, 3a exists in a mixture with Watson-Crick and reversed Watson-Crick arrangements of the two bases, depending on solvent, concentration and anions.

KW - 7,9-Dimethylguanine

KW - Metal-modified base pairs

KW - Pt complex

UR - https://www.scopus.com/pages/publications/0030948263

U2 - 10.1007/s007750050131

DO - 10.1007/s007750050131

M3 - Article

SN - 0949-8257

VL - 2

SP - 256

EP - 264

JO - Journal of Biological Inorganic Chemistry

JF - Journal of Biological Inorganic Chemistry

IS - 2

ER -

Metal-modified nucleobase pairs involving 7,9-dimethylguanine: trans- a₂Pt(II) analogues (a = NH₃ or CH₃NH₂) of Watson-Crick GC and homo GG pairs

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