Metabolic studies with nonnutritive sweeteners cyclooctylsulfamate and 4‐methylcyclohexylsulfamate

The nonnutritive sweeteners cyclooctylsulfamate and 4‐methylcyclohexylsulfamate were fed separately to female Wistar albino rats, and the urine was examined for the possible metabolites cyclooctylamine, cyclooctanone, cyclooctanol, 4‐methylcyclohexylamine, 4‐methylcyclohexanone, and cis‐ and trans ‐4‐methylcyclohexanols. The average percent conversions to cyclooctylamine, cyclooctanone, and cyclooctanol were 0.127, 0.08, and 0.092, respectively. The average percent conversions to 4‐methylcyclohexylamine and 4‐methylcyclohexanone were 0.007 and 0.0013, respectively. No cis‐ or trans‐4‐methylcyclo‐hexanol metabolites were found. With cyclooctylsulfamate, 42% was recovered unchanged from the urine. Cyclooctyl‐ and cycloheptylsulfa‐mates were metabolized to a greater extent than cyclopentylsulfamate, which, in turn, was metabolized to a greater extent than cyclohexylsulfamate (cyclamate) and 4‐methylcyclohexylsulfamate.