Mechanisms for ATP-dependent chromatin remodelling: Farewell to the tuna-can octamer?

Andrew Flaus; Tom Owen-Hughes

doi:10.1016/j.gde.2004.01.007

Mechanisms for ATP-dependent chromatin remodelling: Farewell to the tuna-can octamer?

Andrew Flaus, Tom Owen-Hughes

University of Dundee

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

135 Citations (Scopus)

Abstract

ATP-dependent chromatin remodelling enzymes act to alter chromatin structure during gene regulation. Studies of the ATPase motors that drive these enzymes support the notion that they function as ATP-dependent DNA translocases with limited processivity. The action of these enzymes on nucleosomes results in the alteration of nucleosome positioning and structure. Recent studies have shown that ATP-dependent chromatin remodelling can also either remove or exchange histone dimers between nucleosomes. This provides a new means by which the incorporation of histone variants can be directed. Additional observations support roles for ATP-dependent remodelling enzymes throughout the transcription cycle.

Original language	English
Pages (from-to)	165-173
Number of pages	9
Journal	Current Opinion in Genetics and Development
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/j.gde.2004.01.007
Publication status	Published - Apr 2004
Externally published	Yes

Keywords

ACF
ARP
ATP-utilising chromatin assembly and remodelling factor
ATRX
Actin-related protein
CHRAC
Chromatin accessibility complex
FACT
Facilitates chromatin transcription
X-linked form of syndromal mental retardation associated with alpha thalassaemia

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10.1016/j.gde.2004.01.007

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title = "Mechanisms for ATP-dependent chromatin remodelling: Farewell to the tuna-can octamer?",

abstract = "ATP-dependent chromatin remodelling enzymes act to alter chromatin structure during gene regulation. Studies of the ATPase motors that drive these enzymes support the notion that they function as ATP-dependent DNA translocases with limited processivity. The action of these enzymes on nucleosomes results in the alteration of nucleosome positioning and structure. Recent studies have shown that ATP-dependent chromatin remodelling can also either remove or exchange histone dimers between nucleosomes. This provides a new means by which the incorporation of histone variants can be directed. Additional observations support roles for ATP-dependent remodelling enzymes throughout the transcription cycle.",

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T1 - Mechanisms for ATP-dependent chromatin remodelling

T2 - Farewell to the tuna-can octamer?

AU - Flaus, Andrew

AU - Owen-Hughes, Tom

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Y1 - 2004/4

N2 - ATP-dependent chromatin remodelling enzymes act to alter chromatin structure during gene regulation. Studies of the ATPase motors that drive these enzymes support the notion that they function as ATP-dependent DNA translocases with limited processivity. The action of these enzymes on nucleosomes results in the alteration of nucleosome positioning and structure. Recent studies have shown that ATP-dependent chromatin remodelling can also either remove or exchange histone dimers between nucleosomes. This provides a new means by which the incorporation of histone variants can be directed. Additional observations support roles for ATP-dependent remodelling enzymes throughout the transcription cycle.

AB - ATP-dependent chromatin remodelling enzymes act to alter chromatin structure during gene regulation. Studies of the ATPase motors that drive these enzymes support the notion that they function as ATP-dependent DNA translocases with limited processivity. The action of these enzymes on nucleosomes results in the alteration of nucleosome positioning and structure. Recent studies have shown that ATP-dependent chromatin remodelling can also either remove or exchange histone dimers between nucleosomes. This provides a new means by which the incorporation of histone variants can be directed. Additional observations support roles for ATP-dependent remodelling enzymes throughout the transcription cycle.

KW - ACF

KW - ARP

KW - ATP-utilising chromatin assembly and remodelling factor

KW - ATRX

KW - Actin-related protein

KW - CHRAC

KW - Chromatin accessibility complex

KW - FACT

KW - Facilitates chromatin transcription

KW - X-linked form of syndromal mental retardation associated with alpha thalassaemia

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U2 - 10.1016/j.gde.2004.01.007

DO - 10.1016/j.gde.2004.01.007

M3 - Review article

SN - 0959-437X

VL - 14

SP - 165

EP - 173

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 2

ER -

Mechanisms for ATP-dependent chromatin remodelling: Farewell to the tuna-can octamer?

Abstract

Keywords

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