Mechanism of the acid-catalyzed hydrolysis of N-acylsulfamates

  • William J. Spillane
  • , Jean Baptiste Malaubier

Research output: Contribution to a Journal (Peer & Non Peer)Articlepeer-review

7 Citations (Scopus)

Abstract

The kinetics of hydrolysis of a series of N-acylsulfamate esters p-XC6H4OSO2NHCOR as models for more complex, biologically important compounds has been examined. Structure-reactivity, solvent-reactivity, thermodynamic data, etc. support a bimolecular mechanism involving water in the transition state (TS).

Original languageEnglish
Pages (from-to)7574-7577
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number43
DOIs
Publication statusPublished - 22 Oct 2007

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