Mechanism of the acid-catalyzed hydrolysis of N-acylsulfamates

William J. Spillane; Jean Baptiste Malaubier

doi:10.1016/j.tetlet.2007.08.107

Mechanism of the acid-catalyzed hydrolysis of N-acylsulfamates

William J. Spillane
, Jean Baptiste Malaubier

Cellular & Molecular Medicine

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

7 Citations (Scopus)

Abstract

The kinetics of hydrolysis of a series of N-acylsulfamate esters p-XC₆H₄OSO₂NHCOR as models for more complex, biologically important compounds has been examined. Structure-reactivity, solvent-reactivity, thermodynamic data, etc. support a bimolecular mechanism involving water in the transition state (TS).

Original language	English
Pages (from-to)	7574-7577
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2007.08.107
Publication status	Published - 22 Oct 2007

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10.1016/j.tetlet.2007.08.107

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title = "Mechanism of the acid-catalyzed hydrolysis of N-acylsulfamates",

abstract = "The kinetics of hydrolysis of a series of N-acylsulfamate esters p-XC6H4OSO2NHCOR as models for more complex, biologically important compounds has been examined. Structure-reactivity, solvent-reactivity, thermodynamic data, etc. support a bimolecular mechanism involving water in the transition state (TS).",

author = "Spillane, \{William J.\} and Malaubier, \{Jean Baptiste\}",

year = "2007",

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T1 - Mechanism of the acid-catalyzed hydrolysis of N-acylsulfamates

AU - Spillane, William J.

AU - Malaubier, Jean Baptiste

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N2 - The kinetics of hydrolysis of a series of N-acylsulfamate esters p-XC6H4OSO2NHCOR as models for more complex, biologically important compounds has been examined. Structure-reactivity, solvent-reactivity, thermodynamic data, etc. support a bimolecular mechanism involving water in the transition state (TS).

AB - The kinetics of hydrolysis of a series of N-acylsulfamate esters p-XC6H4OSO2NHCOR as models for more complex, biologically important compounds has been examined. Structure-reactivity, solvent-reactivity, thermodynamic data, etc. support a bimolecular mechanism involving water in the transition state (TS).

UR - https://www.scopus.com/pages/publications/34548847734

U2 - 10.1016/j.tetlet.2007.08.107

DO - 10.1016/j.tetlet.2007.08.107

M3 - Article

SN - 0040-4039

VL - 48

SP - 7574

EP - 7577

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

Mechanism of the acid-catalyzed hydrolysis of N-acylsulfamates

Abstract

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