Measuring antimicrobial activity against biofilm bacteria

Standardization of methodology and interpretation has proved essential to scientific progress in studies of the activity of antimicrobial agents against planktonic bacteria. Current studies of antimicrobial activity against biofilm bacteria lack standardization of methodology. The principles applied to standardization of methods for planktonic bacteria can serve as a template in developing standards for studying biofilm bacteria. Such standards are essential to allow meaningful comparison between published studies.