Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery

M. A.F. Kendall; N. J. Quinlan; S. J. Thorpe; R. W. Ainsworth; B. J. Bellhouse

doi:10.1007/s00348-004-0792-4

Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery

M. A.F. Kendall
, N. J. Quinlan
, S. J. Thorpe
, R. W. Ainsworth
, B. J. Bellhouse

Mechanical Engineering

University of Oxford

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

46 Citations (Scopus)

Abstract

A unique system has been developed based upon the concept of accelerating pharmaceutical agents in particle form with a gas flow to attain sufficient momentum to enter the epidermis of human skin and achieve a pharmacological endpoint. This paper presents an experimental investigation of the transient gas and particle dynamics within a transonic converging-diverging nozzle prototype. The primary gas flow regimes are identified through Pitot-static pressure surveys and schlieren images with a high frame rate. The action of the gas flow-field in imparting momentum to the drug particles is investigated through schlieren imaging and time-resolved Doppler global velocimetry (DGV).

Original language	English
Pages (from-to)	128-136
Number of pages	9
Journal	Experiments in Fluids
Volume	37
Issue number	1
DOIs	https://doi.org/10.1007/s00348-004-0792-4
Publication status	Published - Jul 2004

Access to Document

10.1007/s00348-004-0792-4

Cite this

@article{a124a7e027fa4380a3fc5fec007c7275,

title = "Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery",

abstract = "A unique system has been developed based upon the concept of accelerating pharmaceutical agents in particle form with a gas flow to attain sufficient momentum to enter the epidermis of human skin and achieve a pharmacological endpoint. This paper presents an experimental investigation of the transient gas and particle dynamics within a transonic converging-diverging nozzle prototype. The primary gas flow regimes are identified through Pitot-static pressure surveys and schlieren images with a high frame rate. The action of the gas flow-field in imparting momentum to the drug particles is investigated through schlieren imaging and time-resolved Doppler global velocimetry (DGV).",

author = "Kendall, \{M. A.F.\} and Quinlan, \{N. J.\} and Thorpe, \{S. J.\} and Ainsworth, \{R. W.\} and Bellhouse, \{B. J.\}",

year = "2004",

month = jul,

doi = "10.1007/s00348-004-0792-4",

language = "English",

volume = "37",

pages = "128--136",

journal = "Experiments in Fluids",

issn = "0723-4864",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery

AU - Kendall, M. A.F.

AU - Quinlan, N. J.

AU - Thorpe, S. J.

AU - Ainsworth, R. W.

AU - Bellhouse, B. J.

PY - 2004/7

Y1 - 2004/7

N2 - A unique system has been developed based upon the concept of accelerating pharmaceutical agents in particle form with a gas flow to attain sufficient momentum to enter the epidermis of human skin and achieve a pharmacological endpoint. This paper presents an experimental investigation of the transient gas and particle dynamics within a transonic converging-diverging nozzle prototype. The primary gas flow regimes are identified through Pitot-static pressure surveys and schlieren images with a high frame rate. The action of the gas flow-field in imparting momentum to the drug particles is investigated through schlieren imaging and time-resolved Doppler global velocimetry (DGV).

AB - A unique system has been developed based upon the concept of accelerating pharmaceutical agents in particle form with a gas flow to attain sufficient momentum to enter the epidermis of human skin and achieve a pharmacological endpoint. This paper presents an experimental investigation of the transient gas and particle dynamics within a transonic converging-diverging nozzle prototype. The primary gas flow regimes are identified through Pitot-static pressure surveys and schlieren images with a high frame rate. The action of the gas flow-field in imparting momentum to the drug particles is investigated through schlieren imaging and time-resolved Doppler global velocimetry (DGV).

UR - https://www.scopus.com/pages/publications/3142782787

U2 - 10.1007/s00348-004-0792-4

DO - 10.1007/s00348-004-0792-4

M3 - Article

SN - 0723-4864

VL - 37

SP - 128

EP - 136

JO - Experiments in Fluids

JF - Experiments in Fluids

IS - 1

ER -

Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery

Abstract

Access to Document

Other files and links

Fingerprint

Cite this