Mammalian Target of Rapamycin as a Target in Hematological Malignancies

Isam A. Abdel-Karim; Francis J. Giles

doi:10.1016/j.currproblcancer.2008.05.001

Mammalian Target of Rapamycin as a Target in Hematological Malignancies

Isam A. Abdel-Karim, Francis J. Giles

University of Texas Health Science Center at San Antonio

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

12 Citations (Scopus)

Abstract

Despite significant advances in the treatment of hematological malignancies over the previous decades, morbidity and mortality from theses disorders still remain high. New discoveries in the pathways involved in the pathophysiology led to new thinking in drug discovery. mTOR inhibitors are new and viable options for patients with these malignancies. We hope that newer clinical data will bring about new options in this field.

Original language	English
Pages (from-to)	161-177
Number of pages	17
Journal	Current Problems in Cancer
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.currproblcancer.2008.05.001
Publication status	Published - Jul 2008
Externally published	Yes

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10.1016/j.currproblcancer.2008.05.001

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title = "Mammalian Target of Rapamycin as a Target in Hematological Malignancies",

abstract = "Despite significant advances in the treatment of hematological malignancies over the previous decades, morbidity and mortality from theses disorders still remain high. New discoveries in the pathways involved in the pathophysiology led to new thinking in drug discovery. mTOR inhibitors are new and viable options for patients with these malignancies. We hope that newer clinical data will bring about new options in this field.",

author = "Abdel-Karim, {Isam A.} and Giles, {Francis J.}",

year = "2008",

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AU - Abdel-Karim, Isam A.

AU - Giles, Francis J.

PY - 2008/7

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N2 - Despite significant advances in the treatment of hematological malignancies over the previous decades, morbidity and mortality from theses disorders still remain high. New discoveries in the pathways involved in the pathophysiology led to new thinking in drug discovery. mTOR inhibitors are new and viable options for patients with these malignancies. We hope that newer clinical data will bring about new options in this field.

AB - Despite significant advances in the treatment of hematological malignancies over the previous decades, morbidity and mortality from theses disorders still remain high. New discoveries in the pathways involved in the pathophysiology led to new thinking in drug discovery. mTOR inhibitors are new and viable options for patients with these malignancies. We hope that newer clinical data will bring about new options in this field.

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U2 - 10.1016/j.currproblcancer.2008.05.001

DO - 10.1016/j.currproblcancer.2008.05.001

M3 - Article

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AN - SCOPUS:48949119272

SN - 0147-0272

VL - 32

SP - 161

EP - 177

JO - Current Problems in Cancer

JF - Current Problems in Cancer

IS - 4

ER -

Mammalian Target of Rapamycin as a Target in Hematological Malignancies

Abstract

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