Malignant histiocytosis of the intestine: A T-cell lymphoma

P. G. Isaacson; Jo Spencer; C. E. Connolly; D. J. Pollock; H. Stein; N. T.J. O'Connor; D. H. Bevan; N. Kirkham; J. S. Wainscoat; D. Y. Mason

doi:10.1016/S0140-6736(85)92930-7

Malignant histiocytosis of the intestine: A T-cell lymphoma

P. G. Isaacson, Jo Spencer, C. E. Connolly, D. J. Pollock, H. Stein, N. T.J. O'Connor, D. H. Bevan, N. Kirkham, J. S. Wainscoat, D. Y. Mason

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Abstract

Malignant lymphoma complicating coeliac disease has been characterised on morphological and immunocytochemical grounds as malignant histiocytosis of the intestine (MHI). Fresh tissue from four cases of MHI was studied by means of a panel of monoclonal antibodies; in three cases tumour DNA was studied for immunoglobulin and T-cell-receptor (TCR) gene rearrangement. Immunocytochemistry showed a T-cell phenotype in all four cases, confirmed by the demonstration of a rearranged TCR β-chain gene in the three cases studied. Lymphoma complicating coeliac disease thus appears to be of T-cell, rather than histiocyte, origin.

Original language	English
Pages (from-to)	688-691
Number of pages	4
Journal	The Lancet
Volume	326
Issue number	8457
DOIs	https://doi.org/10.1016/S0140-6736(85)92930-7
Publication status	Published - 1985
Externally published	Yes

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@article{32823f1cc5e2484fb7cd71c1c68fda73,

title = "Malignant histiocytosis of the intestine: A T-cell lymphoma",

abstract = "Malignant lymphoma complicating coeliac disease has been characterised on morphological and immunocytochemical grounds as malignant histiocytosis of the intestine (MHI). Fresh tissue from four cases of MHI was studied by means of a panel of monoclonal antibodies; in three cases tumour DNA was studied for immunoglobulin and T-cell-receptor (TCR) gene rearrangement. Immunocytochemistry showed a T-cell phenotype in all four cases, confirmed by the demonstration of a rearranged TCR β-chain gene in the three cases studied. Lymphoma complicating coeliac disease thus appears to be of T-cell, rather than histiocyte, origin.",

author = "Isaacson, {P. G.} and Jo Spencer and Connolly, {C. E.} and Pollock, {D. J.} and H. Stein and O'Connor, {N. T.J.} and Bevan, {D. H.} and N. Kirkham and Wainscoat, {J. S.} and Mason, {D. Y.}",

year = "1985",

doi = "10.1016/S0140-6736(85)92930-7",

language = "English",

volume = "326",

pages = "688--691",

journal = "The Lancet",

issn = "0140-6736",

number = "8457",

}

TY - JOUR

T1 - Malignant histiocytosis of the intestine

T2 - A T-cell lymphoma

AU - Isaacson, P. G.

AU - Spencer, Jo

AU - Connolly, C. E.

AU - Pollock, D. J.

AU - Stein, H.

AU - O'Connor, N. T.J.

AU - Bevan, D. H.

AU - Kirkham, N.

AU - Wainscoat, J. S.

AU - Mason, D. Y.

PY - 1985

Y1 - 1985

N2 - Malignant lymphoma complicating coeliac disease has been characterised on morphological and immunocytochemical grounds as malignant histiocytosis of the intestine (MHI). Fresh tissue from four cases of MHI was studied by means of a panel of monoclonal antibodies; in three cases tumour DNA was studied for immunoglobulin and T-cell-receptor (TCR) gene rearrangement. Immunocytochemistry showed a T-cell phenotype in all four cases, confirmed by the demonstration of a rearranged TCR β-chain gene in the three cases studied. Lymphoma complicating coeliac disease thus appears to be of T-cell, rather than histiocyte, origin.

AB - Malignant lymphoma complicating coeliac disease has been characterised on morphological and immunocytochemical grounds as malignant histiocytosis of the intestine (MHI). Fresh tissue from four cases of MHI was studied by means of a panel of monoclonal antibodies; in three cases tumour DNA was studied for immunoglobulin and T-cell-receptor (TCR) gene rearrangement. Immunocytochemistry showed a T-cell phenotype in all four cases, confirmed by the demonstration of a rearranged TCR β-chain gene in the three cases studied. Lymphoma complicating coeliac disease thus appears to be of T-cell, rather than histiocyte, origin.

UR - http://www.scopus.com/inward/record.url?scp=0021971904&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(85)92930-7

DO - 10.1016/S0140-6736(85)92930-7

M3 - Article

C2 - 2863677

AN - SCOPUS:0021971904

SN - 0140-6736

VL - 326

SP - 688

EP - 691

JO - The Lancet

JF - The Lancet

IS - 8457

ER -

Malignant histiocytosis of the intestine: A T-cell lymphoma

Abstract

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