Linkage disequilibrium mapping provides evidence for a susceptibility gene for reading disability on chromosome 6p

D. Turic; D. W. Morris; L. Robinson; M. Duke; A. Grierson; R. Raha-Chowdhury; L. Southgate; V. Webb; M. Hamshere; N. Williams; P. McGuffin; J. Stevenson; M. Krawczak; M. J. Owen; M. C. O'Donovan; J. Williams

Linkage disequilibrium mapping provides evidence for a susceptibility gene for reading disability on chromosome 6p

D. Turic
, D. W. Morris
, L. Robinson
, M. Duke
, A. Grierson
, R. Raha-Chowdhury
, L. Southgate
, V. Webb
, M. Hamshere
, N. Williams
, P. McGuffin
, J. Stevenson
, M. Krawczak
, M. J. Owen
, M. C. O'Donovan
, J. Williams

Cardiff University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

3 Citations (Scopus)

Abstract

Replicated linkage analyses provide compelling evidence that chromosome 6 contains at least one gene contributing to reading disability (RD). We used a two-stage family-based linkage disequilibrium approach to map this gene or genes. In two samples of parent/RD proband trios, (Stage 1:103 trios; Stage 2:77 trios), we tested 25 polymorphic markers spanning the region of putative linkage (D6S1629-D6S109) for association with RD. We found significant (p=0.0001) evidence of association with RD with marker haplotypes in at least one region of approximately 1.5 Mb, which replicated in a second stage sample (p=0.0001). These results further support the presence of a susceptibility gene for RD on chromosome 6p, and provide a more precise estimate of its location. We are currently analyzing genes that map to this region that are also thought to play an important role in neuronal functioning.

Original language	English
Pages (from-to)	556
Number of pages	1
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	96
Issue number	4
Publication status	Published - 7 Aug 2000
Externally published	Yes

Cite this

Turic, D., Morris, D. W., Robinson, L., Duke, M., Grierson, A., Raha-Chowdhury, R., Southgate, L., Webb, V., Hamshere, M., Williams, N., McGuffin, P., Stevenson, J., Krawczak, M., Owen, M. J., O'Donovan, M. C., & Williams, J. (2000). Linkage disequilibrium mapping provides evidence for a susceptibility gene for reading disability on chromosome 6p. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 96(4), 556.

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title = "Linkage disequilibrium mapping provides evidence for a susceptibility gene for reading disability on chromosome 6p",

abstract = "Replicated linkage analyses provide compelling evidence that chromosome 6 contains at least one gene contributing to reading disability (RD). We used a two-stage family-based linkage disequilibrium approach to map this gene or genes. In two samples of parent/RD proband trios, (Stage 1:103 trios; Stage 2:77 trios), we tested 25 polymorphic markers spanning the region of putative linkage (D6S1629-D6S109) for association with RD. We found significant (p=0.0001) evidence of association with RD with marker haplotypes in at least one region of approximately 1.5 Mb, which replicated in a second stage sample (p=0.0001). These results further support the presence of a susceptibility gene for RD on chromosome 6p, and provide a more precise estimate of its location. We are currently analyzing genes that map to this region that are also thought to play an important role in neuronal functioning.",

author = "D. Turic and Morris, \{D. W.\} and L. Robinson and M. Duke and A. Grierson and R. Raha-Chowdhury and L. Southgate and V. Webb and M. Hamshere and N. Williams and P. McGuffin and J. Stevenson and M. Krawczak and Owen, \{M. J.\} and O'Donovan, \{M. C.\} and J. Williams",

year = "2000",

month = aug,

day = "7",

language = "English",

volume = "96",

pages = "556",

journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",

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Turic, D, Morris, DW, Robinson, L, Duke, M, Grierson, A, Raha-Chowdhury, R, Southgate, L, Webb, V, Hamshere, M, Williams, N, McGuffin, P, Stevenson, J, Krawczak, M, Owen, MJ, O'Donovan, MC & Williams, J 2000, 'Linkage disequilibrium mapping provides evidence for a susceptibility gene for reading disability on chromosome 6p', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 96, no. 4, pp. 556.

TY - JOUR

T1 - Linkage disequilibrium mapping provides evidence for a susceptibility gene for reading disability on chromosome 6p

AU - Turic, D.

AU - Morris, D. W.

AU - Robinson, L.

AU - Duke, M.

AU - Grierson, A.

AU - Raha-Chowdhury, R.

AU - Southgate, L.

AU - Webb, V.

AU - Hamshere, M.

AU - Williams, N.

AU - McGuffin, P.

AU - Stevenson, J.

AU - Krawczak, M.

AU - Owen, M. J.

AU - O'Donovan, M. C.

AU - Williams, J.

PY - 2000/8/7

Y1 - 2000/8/7

N2 - Replicated linkage analyses provide compelling evidence that chromosome 6 contains at least one gene contributing to reading disability (RD). We used a two-stage family-based linkage disequilibrium approach to map this gene or genes. In two samples of parent/RD proband trios, (Stage 1:103 trios; Stage 2:77 trios), we tested 25 polymorphic markers spanning the region of putative linkage (D6S1629-D6S109) for association with RD. We found significant (p=0.0001) evidence of association with RD with marker haplotypes in at least one region of approximately 1.5 Mb, which replicated in a second stage sample (p=0.0001). These results further support the presence of a susceptibility gene for RD on chromosome 6p, and provide a more precise estimate of its location. We are currently analyzing genes that map to this region that are also thought to play an important role in neuronal functioning.

AB - Replicated linkage analyses provide compelling evidence that chromosome 6 contains at least one gene contributing to reading disability (RD). We used a two-stage family-based linkage disequilibrium approach to map this gene or genes. In two samples of parent/RD proband trios, (Stage 1:103 trios; Stage 2:77 trios), we tested 25 polymorphic markers spanning the region of putative linkage (D6S1629-D6S109) for association with RD. We found significant (p=0.0001) evidence of association with RD with marker haplotypes in at least one region of approximately 1.5 Mb, which replicated in a second stage sample (p=0.0001). These results further support the presence of a susceptibility gene for RD on chromosome 6p, and provide a more precise estimate of its location. We are currently analyzing genes that map to this region that are also thought to play an important role in neuronal functioning.

UR - https://www.scopus.com/pages/publications/0004454341

M3 - Article

AN - SCOPUS:0004454341

SN - 1552-4841

VL - 96

SP - 556

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

IS - 4

ER -

Linkage disequilibrium mapping provides evidence for a susceptibility gene for reading disability on chromosome 6p

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