TY - JOUR
T1 - Ligerin, an antiproliferative chlorinated sesquiterpenoid from a marine-derived penicillium strain
AU - Vansteelandt, Marieke
AU - Blanchet, Elodie
AU - Egorov, Maxim
AU - Petit, Fabien
AU - Toupet, Loïc
AU - Bondon, Arnaud
AU - Monteau, Fabrice
AU - Bizec, Bruno
AU - Thomas, Olivier P.
AU - Pouchus, Yves François
AU - Bot, Ronan Le
AU - Grovel, Olivier
PY - 2013/2/22
Y1 - 2013/2/22
N2 - A new chlorinated sesquiterpenoid analogue of fumagillin, ligerin (1), was isolated from a marine-derived strain of Penicillium, belonging to the subgenus Penicillium, along with the known compounds penicillic acid (2), orcinol, and orsellinic acid. Chemical structures were established by an interpretation of spectroscopic data including IR, UV, and HRESIMS, together with analyses of 1D and 2D NMR spectra and X-ray analysis for the determination of the absolute configuration. Ligerin (1) displayed strong inhibitory activity against an osteosarcoma cell line. This is the first report of the isolation of a fumagillin analogue from a marine-derived Penicillium strain.
AB - A new chlorinated sesquiterpenoid analogue of fumagillin, ligerin (1), was isolated from a marine-derived strain of Penicillium, belonging to the subgenus Penicillium, along with the known compounds penicillic acid (2), orcinol, and orsellinic acid. Chemical structures were established by an interpretation of spectroscopic data including IR, UV, and HRESIMS, together with analyses of 1D and 2D NMR spectra and X-ray analysis for the determination of the absolute configuration. Ligerin (1) displayed strong inhibitory activity against an osteosarcoma cell line. This is the first report of the isolation of a fumagillin analogue from a marine-derived Penicillium strain.
UR - https://www.scopus.com/pages/publications/84876735793
U2 - 10.1021/np3007364
DO - 10.1021/np3007364
M3 - Article
SN - 0163-3864
VL - 76
SP - 297
EP - 301
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -
