Lentiviral vector-mediated knockdown of the NG2 [corrected] proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar.

Timothy O'Brien; Peter Dockery; Siobhan S. McMahon

doi:10.1002/jgm.1509

Lentiviral vector-mediated knockdown of the NG2 [corrected] proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar.

Timothy O'Brien, Peter Dockery, Siobhan S. McMahon

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

21 Citations (Scopus)

Abstract

Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. The inhibitory environment is mainly a result of chondroitin sulphate proteoglycans (CSPGs). NG2, [corrected] one of the main inhibitory CSPGs, is up-regulated following spinal cord injury.

Original language	English (Ireland)
Pages (from-to)	863-872
Number of pages	10
Journal	JOURNAL OF GENE MEDICINE
Volume	12
Issue number	11
DOIs	https://doi.org/10.1002/jgm.1509
Publication status	Published - 1 Nov 2010

Keywords

Glial scar
Lentiviral vector
NG2
Neu7 astrocytes
Neurotrophin-3
Spinal cord injury

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Donnelly EM, Strappe PM, McGinley LM, Madigan NN, Geurts E, Rooney GE, Windebank AJ, Fraher J, Dockery P, O'Brien T, McMahon SS

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10.1002/jgm.1509

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abstract = "Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. The inhibitory environment is mainly a result of chondroitin sulphate proteoglycans (CSPGs). NG2, [corrected] one of the main inhibitory CSPGs, is up-regulated following spinal cord injury.",

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Lentiviral vector-mediated knockdown of the NG2 [corrected] proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. / O'Brien, Timothy ; Dockery, Peter ; McMahon, Siobhan S.
In: JOURNAL OF GENE MEDICINE, Vol. 12, No. 11, 01.11.2010, p. 863-872.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

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Lentiviral vector-mediated knockdown of the NG2 [corrected] proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar.

Abstract

Keywords

Authors (Note for portal: view the doc link for the full list of authors)

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