Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.

Siobhan Mcmahon; Yolanda Garcia; Peter Dockery; Timothy O'Brien

doi:10.3109/14653249.2012.714865

Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.

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Abstract

In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury (SCI).

Original language	English (Ireland)
Pages (from-to)	1235-1244
Number of pages	10
Journal	Cytotherapy
Volume	14
Issue number	10
DOIs	https://doi.org/10.3109/14653249.2012.714865
Publication status	Published - 1 Nov 2012

Keywords

NG2
astrocytes
axon regeneration
chondroitin sulfate proteoglycans
glial scar
microglia
neurotrophin-3
spinal cord injury

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Donnelly EM, Madigan NN, Rooney GE, Knight A, Chen B, Ball B, Kinnavane L, Garcia Y, Dockery P, Fraher J, Strappe PM, Windebank AJ, O'Brien T, McMahon SS

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10.3109/14653249.2012.714865

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title = "Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.",

abstract = "In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury (SCI).",

keywords = "NG2, astrocytes, axon regeneration, chondroitin sulfate proteoglycans, glial scar, microglia, neurotrophin-3, spinal cord injury",

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AU - O'Brien, Timothy

PY - 2012/11/1

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KW - NG2

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KW - axon regeneration

KW - chondroitin sulfate proteoglycans

KW - glial scar

KW - microglia

KW - neurotrophin-3

KW - spinal cord injury

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Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.

Abstract

Keywords

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