Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.

Eleanor M. Donnelly; Nicolas N. Madigan; Gemma E. Rooney; Andrew Knight; Bingkun Chen; Bret Ball; Lisa Kinnavane; Yolanda Garcia; Peter Dockery; John Fraher; Padraig M. Strappe; Anthony J. Windebank; Timothy O'Brien; Siobhán S. McMahon

doi:10.13025/22308

Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.

Eleanor M. Donnelly
, Nicolas N. Madigan
, Gemma E. Rooney
, Andrew Knight
, Bingkun Chen
, Bret Ball
, Lisa Kinnavane
, Yolanda Garcia
, Peter Dockery
, John Fraher
, Padraig M. Strappe
, Anthony J. Windebank
, Timothy O'Brien
, Siobhán S. McMahon

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

25 Citations (Scopus)

1 Downloads (Pure)

Abstract

In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury (SCI).

Original language	English (Ireland)
Pages (from-to)	1235-1244
Number of pages	10
Journal	Cytotherapy
Volume	14
Issue number	10
DOIs	https://doi.org/10.13025/22308 https://doi.org/10.3109/14653249.2012.714865
Publication status	Published - 1 Nov 2012

Keywords

activated macrophages
astrocytes
axon regeneration
axonal regeneration
chondroitin sulfate proteoglycans
chondroitinase abc
functional recovery
glial scar
inhibitory molecules
microglia
nervous-system injury
neurite outgrowth
neurotrophin-3
NG2
reactive astrocytes
sensory neurons
spinal cord injury

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10.13025/22308Licence: CC BY
10.3109/14653249.2012.714865

McMahon et al Cytotherapy 2012Accepted author manuscript, 1.35 MBLicence: CC BY

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Donnelly, E. M., Madigan, N. N., Rooney, G. E., Knight, A., Chen, B., Ball, B., Kinnavane, L., Garcia, Y., Dockery, P., Fraher, J., Strappe, P. M., Windebank, A. J., O'Brien, T., & McMahon, S. S. (2012). Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord. Cytotherapy, 14(10), 1235-1244. https://doi.org/10.13025/22308, https://doi.org/10.3109/14653249.2012.714865

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title = "Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.",

abstract = "In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury (SCI).",

keywords = "activated macrophages, astrocytes, axon regeneration, axonal regeneration, chondroitin sulfate proteoglycans, chondroitinase abc, functional recovery, glial scar, inhibitory molecules, microglia, nervous-system injury, neurite outgrowth, neurotrophin-3, NG2, reactive astrocytes, sensory neurons, spinal cord injury",

author = "Donnelly, \{Eleanor M.\} and Madigan, \{Nicolas N.\} and Rooney, \{Gemma E.\} and Andrew Knight and Bingkun Chen and Bret Ball and Lisa Kinnavane and Yolanda Garcia and Peter Dockery and John Fraher and Strappe, \{Padraig M.\} and Windebank, \{Anthony J.\} and Timothy O'Brien and McMahon, \{Siobh{\'a}n S.\}",

year = "2012",

month = nov,

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doi = "10.13025/22308",

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Donnelly, EM, Madigan, NN, Rooney, GE, Knight, A, Chen, B, Ball, B, Kinnavane, L, Garcia, Y , Dockery, P, Fraher, J, Strappe, PM, Windebank, AJ, O'Brien, T & McMahon, SS 2012, 'Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.', Cytotherapy, vol. 14, no. 10, pp. 1235-1244. https://doi.org/10.13025/22308, https://doi.org/10.3109/14653249.2012.714865

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T1 - Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.

AU - Donnelly, Eleanor M.

AU - Madigan, Nicolas N.

AU - Rooney, Gemma E.

AU - Knight, Andrew

AU - Chen, Bingkun

AU - Ball, Bret

AU - Kinnavane, Lisa

AU - Garcia, Yolanda

AU - Dockery, Peter

AU - Fraher, John

AU - Strappe, Padraig M.

AU - Windebank, Anthony J.

AU - O'Brien, Timothy

AU - McMahon, Siobhán S.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury (SCI).

AB - In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury (SCI).

KW - activated macrophages

KW - astrocytes

KW - axon regeneration

KW - axonal regeneration

KW - chondroitin sulfate proteoglycans

KW - chondroitinase abc

KW - functional recovery

KW - glial scar

KW - inhibitory molecules

KW - microglia

KW - nervous-system injury

KW - neurite outgrowth

KW - neurotrophin-3

KW - NG2

KW - reactive astrocytes

KW - sensory neurons

KW - spinal cord injury

UR - http://hdl.handle.net/10379/15347

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U2 - 10.13025/22308

DO - 10.13025/22308

M3 - Article

VL - 14

SP - 1235

EP - 1244

JO - Cytotherapy

JF - Cytotherapy

IS - 10

ER -

Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.

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Keywords

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