LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

M. R. Sarker; M. P. Sory; A. P. Boyd; M. Iriarte; G. R. Cornelis

doi:10.1128/iai.66.6.2976-2979.1998

LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

M. R. Sarker, M. P. Sory, A. P. Boyd, M. Iriarte, G. R. Cornelis

Université Catholique de Louvain

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

46 Citations (Scopus)

Abstract

Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

Original language	English
Pages (from-to)	2976-2979
Number of pages	4
Journal	Infection and Immunity
Volume	66
Issue number	6
DOIs	https://doi.org/10.1128/iai.66.6.2976-2979.1998
Publication status	Published - 1998
Externally published	Yes

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10.1128/iai.66.6.2976-2979.1998

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title = "LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells",

abstract = "Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.",

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T1 - LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

AU - Sarker, M. R.

AU - Sory, M. P.

AU - Boyd, A. P.

AU - Iriarte, M.

AU - Cornelis, G. R.

PY - 1998

Y1 - 1998

N2 - Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

AB - Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

UR - https://www.scopus.com/pages/publications/0031811818

U2 - 10.1128/iai.66.6.2976-2979.1998

DO - 10.1128/iai.66.6.2976-2979.1998

M3 - Article

SN - 0019-9567

VL - 66

SP - 2976

EP - 2979

JO - Infection and Immunity

JF - Infection and Immunity

IS - 6

ER -

LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

Abstract

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