Label free nano-sensitive optical imaging beyond resolution limit of the imaging system

Sergey Alexandrov, Ryan McAuley, Rajib Dey, Martin Leahy

Research output: Chapter in Book or Conference Publication/ProceedingConference Publicationpeer-review

Abstract

In this paper, we describe different approaches to improve resolution and get information about structure beyond the resolution limit of the imaging system. The approaches are based on collection of high spatial frequencies of the object using different techniques, including digital holography and spectral encoding of spatial frequency (SESF) approach. Synthetic aperture digital Fourier holography permits formation of the super-resolution images to extract microscopic information using wide field of view and long working distance low-numerical-aperture optics. SESF approach dramatically improves sensitivity to structural changes, up to nanoscale, and can form 2D and 3D nano-sensitive super-resolution images of highly scattering objects. Numerical simulation and experiments demonstrate advantages of these approaches.

Original languageEnglish
Title of host publicationProceedings - 2024 24th International Conference on Transparent Optical Networks, ICTON 2024
EditorsFrancesco Prudenzano, Marian Marciniak
PublisherIEEE Computer Society
ISBN (Electronic)9798350377309
DOIs
Publication statusPublished - 2024
Event24th International Conference on Transparent Optical Networks, ICTON 2024 - Bari, Italy
Duration: 14 Jul 202418 Jul 2024

Publication series

NameInternational Conference on Transparent Optical Networks
ISSN (Print)2162-7339

Conference

Conference24th International Conference on Transparent Optical Networks, ICTON 2024
Country/TerritoryItaly
CityBari
Period14/07/2418/07/24

Keywords

  • biomedical optics
  • Fourier analysis
  • nano-sensitivity
  • optical imaging
  • super-resolution

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